"[Maxims] are not of use to help men forward in the advancement of sciences, or new discoveries of yet unknown truths. Mr. Newton, in his never enough to be admired book, has demonstrated several propositions, which are so many new truths, before unknown to the world, and are further advances in mathematical knowledge: but, for the discovery of these, it was not the general maxims, 'what is, is;' or, 'the whole is bigger than a part,' or the like, that helped him. These were not the clues that led him into the discovery of the truth and certainty of those propositions. Nor was it by them that he got the knowledge of those demonstrations, but by finding out intermediate ideas that showed the agreement or disagreement of the ideas, as expressed in the propositions he demonstrated. This is the greatest exercise and improvement of human understanding in the enlarging of knowledge, and advancing the sciences; wherein they are far enough from receiving any help from the contemplation of these or the like magnified maxims."
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John Locke, An Essay Concerning Humane Understanding (1689), Epistle to the Reader
https://en.wikiquote.org/wiki/Science
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