"Acute fear in response to encountering threat is associated with a distinctive pattern of neural activity distributed through the cerebellum (Ploghaus et al., 1999), limbic system (Knight et al., 2004; LaBar et al., 1998), and cortex (prefrontal: Phelps, Delgado, Nearing and LeDoux, 2004; sensory: Morris et al., 2001; cingulate: Milad et al., 2007; insula: Critchley et al., 2002; motor: Lissek et al., 2014). This dis-tributed network (Saarimäki et al., 2016) enables the rapid detection and appraisal of threat, its saliency to oneself, the employment of executive functioning and memory for decision making and action plan-ning, and the implementation of action plans (Zhu and Thagard, 2002). In addition to generating immediate survival responses, fear systems also modulate vigilance in anticipation of threat caused by environmental cues, perceptual uncertainty, and ambiguity that elicits a sustained fear prior to actual encountering of threat (Fanselow, 1994; Lang et al., 2000; Lehne and Koelsch, 2015). This gives rise to subjective feelings of anxiety, tension, suspense, dread, or foreboding that reflects a generalized antici-patory preparedness for the possibility of potential danger. Several recent studies have shown that spa-tiotemporally distant threats elicit activity in the ventromedial prefrontal cortex, posterior cingulate cor-tex, hippocampus and amygdala, which are associated with a cognitive mechanism of fear that reflects the need for complex information processing and memory retrieval to generate an adaptive and flexible response. A threat that is proximal in space or time, on the other hand, elicits a reactive fear response of immediate action and fight or flight, and which elicits activity in the periaqueductal gray, amygdala, hypothalamus, and middle cingulate cortex (Mobbs et al., 2007; Qi et al., 2018)."
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