"In the United States, most new HIV infections are the result of unprotected RAI with a risk rate of 138 per 10,000 exposures. The CDC lists in order of effectiveness (least to greatest) circumcision of adult males, male condom use, daily PrEP for HIV-negative individuals, and ART for HIV-positive individuals as strategies for the prevention of new HIV infections. Randomized clinical trials conducted among men in sub-Saharan Africa support male circumcision for reducing HIV transmission for the insertive partner during anal intercourse; however, as circumcision trials have not included a large enough number of MSM and many MSM practice both insertive and receptive anal intercourse, the CDC did not definitely conclude that male circumcision reduces risk of HIV acquisition in MSM practicing receptive anal sex."
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