"In any epidemic... let us suppose five hundred of the sick, taken indiscriminately, to be subjected to one kind of treatment, and five hundred others, taken in the same manner, to be treated in a different mode; if the mortality is greater among the first, than among the second, must we not conclude that the treatment was less appropriate, or less efficacious in the first class, than in the second ? It is unavoidable; for among so large a collection, similarities of condition will necessarily be met with, and all things being equal, except the treatment, the conclusion will be rigorous."
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Pierre Charles Alexandre Louis
Pierre Charles Alexandre Louis (14 April 1787 – 22 August 1872) was a French physician known for inventing the "numerical method", a precursor to modern clinical trials, and for his work on infectious diseases and bloodletting.
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