"Has any one ever clearly understood the celebrated story at the beginning of the Bible - of God's mortal terror of science? . . . No one, in fact, has understood it. This priest-book par excellence opens, as is fitting, with the great inner difficulty of the priest: he faces only one great danger; ergo, "God" faces only one great danger. The old God, wholly "spirit," wholly the high-priest, wholly perfect, is promenading his garden: he is bored and trying to kill time. Against boredom even gods struggle in vain. What does he do? He creates man - man is entertaining. . . But then he notices that man is also bored. God's pity for the only form of distress that invades all paradises knows no bounds: so he forthwith creates other animals. God's first mistake: to man these other animals were not entertaining - he sought dominion over them; he did not want to be an "animal" himself. So God created woman. In the act he brought boredom to an end - and also many other things! Woman was the second mistake of God. "Woman, at bottom, is a serpent, Heva" - every priest knows that; "from woman comes every evil in the world" - every priest knows that, too. Ergo, she is also to blame for science. . . It was through woman that man learned to taste of the tree of knowledge. What happened? The old God was seized by mortal terror. Man himself had been his greatest blunder; he had created a rival to himself; science makes men godlike - it is all up with priests and gods when man becomes scientific! Moral: science is the forbidden per se; it alone is forbidden. Science is the first of sins, the germ of all sins, the original sin. This is all there is of morality. "Thou shalt not know" - the rest follows from that."
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Friedrich Nietzsche, The Antichrist, Β§48 (H.L. Mencken trans.).
https://en.wikiquote.org/wiki/Original_sin
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Original sin
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