transhumanists

"I am at last in a position to apologise - which I gladly do publicly - to Laura Deming for my email to her in 2012, about which I had forgotten until the investigator reminded me of it. As STAT reported three weeks ago, I consider that that email would have been a mistake even if she had been five years older, because we were in a mentor-mentee relationship. I catgorically deny Laura's current (though, as she made clear on August 10th, not contemporaneous) view, shared by the investigator, that I sent that email with improper intent - but my email does not become OK just because improper intent is now being misread into it."

"Scientist Aubrey de Grey made inappropriate sexual comments to two female entrepreneurs, independent investigation finds"

"Aubrey de Grey is a sexual predator. For years he has used his position of power in the aging field to attract his victims. These victims include me, Laura Deming, and multiple other anonymous women. Laura was a minor when Aubrey came on to her; I was a SENS-funded student. Aubrey’s proclivities are a long held open secret in the aging field."

"It is at the same level of women in World War II sleeping with Nazis to get information. It is a war against aging here. You have to persuade people to give money. That is honestly who I am. I am the general. .. It is just not possible I could have said anything like this to [Complainant #2] in 2018. […] I would not dream of saying anything remotely along those lines. I have not used any of my staff in terms of womanhood in that way. I put my scientists next to donors to talk science."

"I don't feel the need to subtweet that one - Aubrey is an absolutely terrible human being"

"When I was much younger I had a couple of relationships with women who were very smart but, being teenaged, had not had time to demonstrate it. It was important to them that I not compliment them too much on their (very considerable) physical attributes, and I respected that at the time and still do. But for those of us who have already achieved plenty in life, and who thus have nothing to prove, the same does not apply. I have a mission in life, and I have no compunction whatsoever in furthering it by means that have nothing to do with my intellect, whether that be my ability to feign a reasonably aristocratic accent or my own physical attributes. Similarly, I view it as not only acceptable but positively recommended that those of my colleagues who are similarly committed to this same mission should take whatever advantage may be available, of whatever attributes they may possess, to influence those who have major potential to further that mission - and, to the extent that they do so without even thinking about it, that they not be all coy and in denial they they do so. There’s a war on, my friend; there's no time to be all pompous about some hypothetical greater value of those enviable features that one has earned through hard work over those that one was born with. We need to work with what we have, however we obtained it."

"I had one bad experience with him when I was 17 - he told me in writing that he had an ‘adventurous love life’ and that it had ‘always felt quite jarring’ not to let conversations with me stray in that direction given that ‘[he] could treat [me] as an equal on every other level’. He sent this from his work email, and I’d known him since I was 14."

"we find Dr. de Grey purposefully and knowingly disregarded multiple directives (from the acting Executive Director, this investigator, and his own counsel) to retain the confidentiality of the investigation. In his interview, Dr. de Grey not only admitted to this conduct, he made unreasonable efforts to justify it ..Dr. de Grey’s unapologetic interference with the investigation by reaching out to a witness through a third party and repeatedly posting about the investigation has generated angry attacks on the accusers and perpetuated misinformation (i.e., that he has been exonerated)"

"I define aging as the set of accumulated side effects from metabolism that eventually kills us."

"If we are to bring about real regenerative therapies that will benefit not just future generations, but those of us who are alive today, we must encourage scientists to work on the problem of aging"

"Aubrey is one of the kindest and most generous people I have ever known. He only ever treated me with respect and kindness. I never saw him intentionally disrespect anyone."

"Suppose we encounter an advanced civilization that has engineered a happy biosphere. Population sizes are controlled by cross-species immunocontraception. Free-living herbivores lead idyllic lives in their wildlife parks. Should we urge the reintroduction of starvation, asphyxiation, disemboweling and being eaten alive by predators? Is their regime of compassionate stewardship of the biosphere best abandoned in favour of "re-wilding"? I suspect the advanced civilization would regard human pleas to restore the old Darwinian regime of "Nature, red in tooth and claw" as callous if not borderline sociopathic."

"To be sure, risks abound; but no one is proposing compassionate stewardship of ecosystems by philosophers. Humans are capable of choosing our own future pain-sensitivity too; but any species-wide genomic shift in human pain tolerance will depend on the willingness of prospective parents to use preimplantation genetic screening."

"The reason for sketching what's technically feasible with the tools of synthetic biology is that only after human complicity in the persistence of suffering in the biosphere is acknowledged can we hope to have an informed socio-political debate on the morality of its perpetuation. No serious ethical discussion of free-living animal suffering can begin in the absence of recognition of human responsibility for nonhuman well-being."

"A few centuries from now, if involuntary suffering still exists in the world, the explanation for its persistence won't be that we've run out of computational resources to phase out its biological signature, but rather that rational agents – for reasons unknown – will have chosen to preserve it."

"What right have humans to impose our values on members of another race or species? The charge is seductive but misplaced. There is no anthropomorphism here, no imposition of human values on alien minds. Human and nonhuman animals are alike in an ethically critical respect. The pleasure-pain axis is universal to sentient life. No sentient being wants to be harmed – to be asphyxiated, dismembered, or eaten alive. The wishes of a terrified toddler or a fleeing zebra to flourish unmolested are not open to doubt even in the absence of the verbal capacity to say so."

"[H]uman nature as encoded in our DNA isn't immutable. Mankind's barbaric track-record to date is an unreliable guide to the future. If Homo sapiens' nastier alleles and their more sinister combinations can be silenced or edited out of the genome, and new improved code-sequences inserted instead, then the pessimists will be confounded. A major discontinuity in the development of life lies ahead. Providentially, we've learned that the DNA-driven world isn't written in God-given proprietary code it would be hubris to tamper with, but in bug-ridden open source amenable to improvement."

"Why expect a false theory of the world, i.e. classical physics, to yield a true account of consciousness?"

"It is hard to imagine an experience more horrific than being eaten alive. Most of us would prefer not to imagine what it must feel like. Note that the photographer here had to persuade the park ranger to violate the park rules and put the baby elephant out of his misery. By analogy, suppose it were lawful to visit Third World countries for photoshoots but illegal to "interfere" and help a stricken human baby. Is there a fundamental difference between "ethical" intervention to help humans and "sentimental" pleas to "interfere" and help non-humans? Should we encourage the preservation of life-forms such as the hyena in their current guise? Or do the value judgements underlying the "science" of conservation biology need to be re-examined?"

"From a young age, I've viewed the animals we abuse and kill as akin - functionally, intellectually and emotionally - to small children. Small children are vulnerable. Typically, they don't need "liberating". Infants and toddlers in particular need looking after. The problem - when I was a teenager - was that most of interventions I could think of to alleviate wild animal suffering might easily make things worse in the long run. Thus if we sought to rescue herbivores, then obligate carnivores (and their young) would starve. If we were to phase out carnivorous predators altogether, then there would a population explosion of "prey" species. Lots of herbivores would then starve too. The food chain seemed an inexorable fact of the world - a fact as immutable as, say, the Second Law of Thermodynamics. Only after reading Eric Drexler's classic "Engines of Creation: The Coming Era of Nanotechnology" did I gradually come to realize that there were technical solutions to all these problems - notably in vitro meat, immunocontraception, neurochips to modulate behaviour, nanobots to manage marine ecosystems, and ultimately rewriting the vertebrate genome."

"My own view of the risks and uncertainties is that there is a critical distinction between trying to abolish suffering exclusively via social reform and abolishing suffering directly via biotechnology. As we know, utopian social experiments typically go wrong, sometimes hideously wrong, and end up causing a lot of suffering instead. The abolitionist project of eradicating the biological substrates of suffering sounds like just another utopian scheme, whether it's touted as a grandiose species-project or simply as a byproduct of the Reproductive Revolution explored here. Although the abolition of psychological pain is arguably no more utopian in principle than pain-free surgery, it could presumably go wrong in unanticipated ways too. Perhaps we'll unwittingly create a fool's paradise. But if and when we ever abolish the molecular underpinning of unpleasant experience, and it becomes physiologically impossible for any sentient being to suffer, we thereby change the very meaning of what it is for anything to "go wrong". Unwelcome surprises where no one gets hurt are very different from unwelcome surprises where they do. For what it's worth, I think the abolition of involuntary suffering is the precondition of any civilised posthuman society; and therefore a risk worth taking."

"Many city-dwellers have a romanticized conception of the living world. From another perspective, some "conservation biologists" favour e.g. "". By contrast, I think any truly compassionate person should be horrified at the terrible suffering of Nature "red in tooth and claw". Why not aim for a cruelty-free world instead?"

"[B]oth natural selection and the historical record offer powerful reasons for doubting the trustworthiness of our naive moral intuitions. So the possibility that human civilisation might be founded upon some monstrous evil should be taken seriously - even if the possibility seems transparently absurd at the time."

"So what is the alternative to traditional anthropocentric ethics? Antispeciesism is not the claim that "All Animals Are Equal", or that all species are of equal value, or that a human or a pig is equivalent to a mosquito. Rather the antispeciesist claims that, other things being equal, equally strong interests should count equally. Experiences that are subjectively negative or positive in hedonic tone to the same degree must count for the same."

"[O]ne might naively suppose that a negative utilitarian would welcome human extinction. But only (trans)humans - or our potential superintelligent successors - are technically capable of phasing out the cruelties of the rest of the living world on Earth. And only (trans)humans - or rather our potential superintelligent successors - are technically capable of assuming stewardship of our entire Hubble volume."

"The biology of suffering in intelligent agents is a deep underlying source of existential risk – and one that can potentially be overcome."

"Getting rid of predation isn't a matter of moralising. A python who kills a small human child isn't morally blameworthy. Nor is a lion who hunts and kills a terrified zebra. In both cases, the victim suffers horribly. But the predator lacks the empathetic and mind-reading skills needed to understand the implications of what s/he is doing. Some humans still display a similar deficit. From the perspective of the victim, the moral status or (lack of) guilty intent of a human or nonhuman predator is irrelevant. Either way, to stand by and watch the snake asphyxiate a child would be almost as morally abhorrent as to kill the child yourself. So why turn this principle on its head with beings of comparable sentience to human infants and toddlers? With power comes complicity."

"In the long run, there is nothing to stop intelligent agents from identifying the molecular signature of experience below hedonic zero and eliminating it altogether — even in insects. Nociception is vital; pain is optional. I tentatively predict that the world's last unpleasant experience in our forward light-cone will be a precisely datable event — perhaps some micro-pain in an obscure marine invertebrate a few centuries hence."

"[L]ike nonhuman animals in human factory farms, free-living nonhumans who are starving - or being disembowelled, asphyxiated or eaten alive - cannot console themselves by chanting the Four Noble Truths of Buddhism. The moral case for helping other sentient beings, regardless or race or species, does not rest on the distress their plight does (or doesn't) cause spectators."

"It's easy to support the status quo if one is not another of its victims."

"If we want eternal life, then we’ll need to rewrite our bug-ridden genetic code and become god-like. “May all that have life be delivered from suffering”, said Gautama Buddha. It’s a wonderful sentiment. Sadly, only hi-tech solutions can ever eradicate suffering from the living world. Compassion alone is not enough."

"Here the question comes down to an analysis of risk-reward ratios - and our basic ethical values, themselves shaped by our evolutionary past. Lest extension of the new reproductive medicine seem too rashly experimental even to contemplate, it's worth recalling that each act of old-fashioned sexual reproduction is itself an untested genetic experiment, the outcome of random mutations and meiotic shuffling of the genetic deck, and with no happy ending to date. So just who are we to accuse of reckless gambling? As it stands, all of us are genetically predestined to grow old and die; and in the course of a lifetime, the great majority of humans will experience periods of intense psychological distress, for instance loneliness and heartache after an unhappy love affair. Our social primate biology ensures that most of us sometimes experience, to a greater or lesser degree, all manner of nasty states that were genetically adaptive in the ancestral environment e.g. jealousy, resentment, anger, and so forth. Hundreds of millions of people in the world today suffer bouts of depression; others live with chronic anxiety. One might say these phenotypes are part of what it means to be human. Worse, we pass a heritable predisposition to these horrible states on to our children."

"Today, empathetic intelligence entails sharing the sorrows of other sentient beings. In our posthuman future, will empathy consist entirely in sharing each other's joys?"

"The negative utilitarian might reply that this formulation of the problem is misleading. We do not live in a notional world where only a pinprick, minor pains, or even just "mild" suffering exists. In the real world, frightful horrors as well as humdrum malaise occur every day. The intensity of suffering is sometimes so dreadful that its victims are prepared to destroy themselves to bring their torment to an end. Each year, some 800,000 people across the planet kill themselves while in the grip of suicidal despair. Tens of millions of people are severely depressed or suffer chronic neuropathic pain. By way of contrast, the genteel conventions of an ethics seminar in academic philosophy, or the scholarly technicalities of a journal article, simply fail to come to terms with the enormity of what's at stake. To talk of a "pinprick" is to trivialise the NU ethical stance."

"[N]othing is too terrible to be true if it is consistent with the laws of nature [...]."

"I argue that what breathes fire into the QM equations is field-theoretic what-it's-likeness: "microqualia" to use a philosopher's term of art. The different values of the solutions to the ultimate physical equations exhaustively yield the abundance of different values of subjectivity. There is no room for dualism; "nomological danglers"; causally inert epiphenomena; classical, porridge-like lumps of otherwise insentient but magically mind-secreting matter, etc. There is no "explanatory gap" because there aren't any material objects - not even brains or nerve cells as commonly (mis)perceived. Instead, over millions of years, non-equilibrium thermodynamics and universal, (neo-)Darwinian principles of natural selection have contrived to organise a minimal and self-intimating subjective sludge of microqualia into complex functional living units. Initially, these units have taken the form of self-replicating, information-bearing biomolecular patterns. Eventually, selection-pressure has given rise to complex minds as well, albeit as just one part of the throwaway host vehicles by which our genes leave copies of themselves. Conscious mind, on this proposal, is a triumph of organisation: our egocentric virtual worlds are warm and gappy QM-coherent states of consciousness. Contra materialist metaphysics, sentience of any kind is not the daily re-enactment of an ontological miracle. Moreover the idea that what-it's-like-ness is the fire in the equations is (at least) consistent with orthodox relativistic quantum field theory - because the theorists' key notions (e.g. that of a field, string, brane, etc) are defined purely mathematically. In other cases, they readily lend themselves to such a reconstruction. Using the word "physical" doesn't add anything of substance."

"When Bernard Marx tells the Savage he will try to secure permission for him and his mother to visit the Other Place, John is initially pleased and excited. Echoing Miranda in The Tempest, he exclaims: "O brave new world that has such people in it." Heavy irony. Like innocent Miranda, he is eager to embrace a way of life he neither knows nor understands. And of course he comes unstuck. Yet if we swallow such fancy literary conceits, then ultimately the joke is on us. It is only funny in the sense there are "jokes" about Auschwitz. For it is Huxley who neither knows nor understands the glory of what lies ahead. A utopian society in which we are sublimely happy will be far better than we can presently imagine, not worse. And it is we, trapped in the emotional squalor of late-Darwinian antiquity, who neither know nor understand the lives of the god-like super-beings we are destined to become."

"[U]nlike positive utilitarianism or so-called preference utilitarianism - neither of which can ever be wholly fulfilled - [negative utilitarianism] seems achievable in full."

"It's not that there are no differences between human and non-human animals, any more than there are no differences between black people and white people, freeborn citizens and slaves, men and women, Jews and gentiles, gays or heterosexuals. The question is rather: are they morally relevant differences? This matters because morally catastrophic consequences can ensue when we latch on to a real but morally irrelevant difference between sentient beings."

"When one is gripped by excruciating physical pain, one is always shocked at just how frightful it can be."

"My own sense of how to behave in a simulation has more traditional roots in the theory of perception. I've long believed that each of us lives in an egocentric simulation of the world run by the mind/brain. Since the zombies of each (waking) simulation have sentient real world counterparts, one should treat them as though they were real. Nonetheless as an angst-ridden teenager, my dawning acceptance of an inferential realist theory of perception made me feel as if I'd been condemned to solitary confinement for life. The sense of loneliness was indescribable. Naïve realism is better for one's mental health."

"Assume, provisionally at any rate, a utilitarian ethic. The abolitionist project follows naturally, in "our" parochial corner of Hilbert space at least. On its completion, if not before, we should aim to develop superintelligence to maximise the well-being of the fragment of the cosmos accessible to beneficent intervention. And when we are sure – absolutely sure – that we have done literally everything we can do to eradicate suffering elsewhere, perhaps we should forget about its very existence."

"[H]ere we come to the nub of the issue: the alleged moral force of the term "natural". If any creature, by its very nature, causes terrible suffering, albeit unwittingly, is it morally wrong to change that nature? If a civilised human were to come to believe s/he had been committing acts that caused grievous pain for no good reason, then s/he would stop - and want other moral agents to prevent the recurrence of such behaviour. May we assume that the same would be true of a lion, if the lion were morally and cognitively "uplifted" so as to understand the ramifications of what (s)he was doing? Or a house cat tormenting a mouse? Or indeed a human sociopath?"

"Given our anthropocentric bias, thinking of non-human vertebrates not just as equivalent in moral status to toddlers or infants, but as though they were toddlers or infants, is a useful exercise. Such reconceptualisation helps correct our lack of empathy for sentient beings whose physical appearance is different from "us". Ethically, the practice of intelligent "anthropomorphism" shouldn't be shunned as unscientific, but embraced insofar as it augments our stunted capacity for empathy. Such anthropomorphism can be a valuable corrective to our cognitive and moral limitations. This is not a plea to be sentimental, simply for impartial benevolence."

"Our present-day neurochemical cocktail, we are asked to believe, is the medium through which alien realms of consciousness can be grasped and neutrally appraised from a third-person perspective. Empirical research suggests this optimism is at best naïve."

"Human intuitions are systematically biased. Evolutionary psychology explains how our moral intuitions and the rationalisations they spawn have been shaped by millennia of natural selection to maximise the inclusive fitness of our genes, not to track the welfare of other sentient beings impartially conceived. Many human cultures have found nothing intuitively wrong with aggressive warfare, slavery, wife-beating, infanticide or female genital mutilation. Ultimately, folk morality is a doomed enterprise as hopeless as folk physics. A mature posthuman ethics, I'd argue, must be committed to the well-being of all sentient life; and mature posthuman technology offers the means to deliver that commitment."

"Suffering exists only because it was good for our genes. Conditionally-activated negative emotions were fitness-enhancing in the ancestral environment. In the current era, apologists for mental pain are serving as the innocent mouthpieces of the nasty bits of code which spawned them."

"Some days will be sublime. Others will be merely wonderful. But critically, there will be one particular texture ("what it feels like") of consciousness that will be missing from our lives; and that will be the texture of nastiness."

"I predict we will abolish suffering throughout the living world. Our descendants will be animated by gradients of genetically pre-programmed well-being that are orders of magnitude richer than today's peak experiences."

"As the neurobiological basis of feeling and emotion is unravelled, and the human genome decoded and rewritten, it will become purely an issue of post-human decision whether negative modes of consciousness are generated in any form or texture whatsoever."