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April 10, 2026

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"The short stature of Pygmy groups around the world has long intrigued anthropologists. It is generally accepted that their small body size is a result of genetic adaptation; however, which genes were selected, and the nature of the underlying selective force(s), remain unknown. The various hypotheses proposed include adaptations to food limitation, thermoregulation, mobility in the forest, and/or short lifespan. A recent study of the HGDP-CEPH populations identified a signal of selection in the insulin growth factor signalling pathway in Biaka Pygmies, which might be associated with short stature, but this signal was not shared with Mbuti Pygmies. By contrast, we found strong signals for selection in both African Pygmy groups at two genes involved in the iodide-dependent thyroid hormone pathway: TRIP4 in Mbuti Pygmies; and IYD in Biaka Pygmies (Fig. 7). Intriguingly, a previous study found a significantly lower frequency of goiter in Efe Pygmies (9.4%) than in Lese Bantu farmers (42.9%). The Efe and Lese live in close proximity to one another in the iodine-deficient Ituri Forest and share similar diets. Moreover, the frequency of goiter in Efe women living in Bantu villages was similar to that of Efe women living in the forest, and the frequency of goiter in offspring with an Efe mother and a Lese father was intermediate between that of Efe and Lese. These observations suggest that the Efe have adapted genetically to an iodine-deficient diet; we suggest that the signals of recent positive selection that we observe at TRIP4 in Mbuti Pygmies and IYD in Biaka Pygmies may reflect such genetic adaptations to an iodine-deficient diet. Furthermore, alterations in the thyroid hormone pathway can cause short stature. We therefore suggest that short stature in these Pygmy groups may have arisen as a consequence of genetic alterations in the thyroid hormone pathway. If this scenario is true, then there are two important implications. First, this would suggest that short stature was not selected for directly in the ancestors of Pygmy groups, but rather arose as an indirect consequence of selection in response to an iodine-deficient diet. Second, since different genes in the thyroid hormone pathway show signals of selection in Mbuti vs. Biaka Pygmies, this would suggest that short stature arose independently in the ancestors of Mbuti and Biaka Pygmies, and not in a common ancestral population. Moreover, most Pygmy-like groups around the world dwell in tropical forests, and hence are likely to have iodine-deficient diets. The possibility that independent adaptations to an iodine-deficient diet might therefore have contributed to the convergent evolution of the short stature phenotype in Pygmy-like groups around the world deserves further investigation."

- Pygmy peoples

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"A viral outbreak has killed more than 6,500 children in the Democratic Republic of the Congo (DRC) and is still spreading through the country. The foe isn’t the feared coronavirus, which has only just reached the DRC. It’s an old, familiar and underestimated adversary: measles. Cases began to spike here in October 2018. Children became weak, feverish and congested, with red eyes and painful sores in their mouths, all with the telltale rash of measles. “We have been running after the virus ever since,” says Balcha Masresha, an epidemiologist with the World Health Organization (WHO) regional Africa office in Brazzaville in the neighbouring Republic of Congo. The situation has mushroomed into what WHO experts say might be the largest documented measles outbreak in one country since the world gained a measles vaccine in 1963 (see ‘Measles cases on the rise’). The highly contagious measles virus continues to spread around the globe. In 2018, cases surged to an estimated 10 million worldwide, with 140,000 deaths, a 58% increase since 2016. In rich countries, scattered measles outbreaks are fuelled by people refusing to vaccinate their children. But in poor countries, the problems are health systems so broken and underfunded that it is nigh-on impossible to deliver the vaccine to people who need it. The DRC’s flood of cases shows why measles will keep flaring up despite efforts to control it. And the situation will only worsen with the COVID-19 pandemic: more than 20 countries have already suspended measles vaccination campaigns as healthcare workers scramble to deal with coronavirus."

- 2019–2020 measles outbreak in the Democratic Republic of the Congo

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"What we’ve been hearing from the panelists is how the global food system works right now... It’s based on large multinational companies, private profits, and very low international transfers to help poor people (sometimes no transfers at all). It’s based on the extreme irresponsibility of powerful countries with regard to the environment. And it’s based on a radical denial of the economic rights of poor people... We’ve just heard from the Minister of the Democratic Republic of the Congo. Many point a finger of blame at the DRC and other poor countries for their poverty. Yet we don’t seem to remember, or want to remember, that starting around 1870, King Leopold of Belgium created a slave colony in the Congo that lasted for around 40 years; and then the government of Belgium ran the colony for another 50 years. In 1961, after independence of the DRC, the CIA then assassinated the DRC’s first popular leader, Patrice Lumumba, and installed a US-backed dictator, Mobutu Sese Seko, for roughly the next 30 years. And in recent years, Glencore and other multinational companies suck out the DRC’s cobalt without paying a level of royalties and taxes. We simply don’t reflect on the real history of the DRC and other poor countries struggling to escape from poverty. Instead, we point fingers at these countries and say, “What’s wrong with you? Why don’t you govern yourselves properly?”"

- Democratic Republic of the Congo

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