"[to Adam, the night before Adam's surgery] Driving! That’s what you want to do? That’s your “Make A Wish”? To drive? We could be having sex with hookers while skydiving, and instead you want to do something I learned to do when I was fifteen!"

"Philip Baker Hall - Alan Lombardo"

"Anna Kendrick - Katherine McKay"

"Andrew Airlie - Dr. Ross"

"[to Katherine] I’m sorry, but, I’m going to have to call you on that. It’s bullshit. That’s what everyone has been saying. “You’ll get better” and “It’ll be fine”. I don’t know why everyone is so fucking scared to say it. “You’re dying, dude”...It makes it worse."

"Matt Frewer - Mitch Barnett"

"Anjelica Huston - Diane Lerner"

"Bryce Dallas Howard - Rachael"

"Joseph Gordon-Levitt - Adam Lerner"

"Seth Rogen - Kyle Hirons"

"[to Adam] You’ll be fine. 50/50! If you were a casino game you’d have the best odds!"

"Ron Feinberg - Doug Atkins"

"Jack Concannon - Himself"

"David Huddleston - Ed McCaskey"

"Abe Gibron - Himself"

"Shelley Fabares - Joy Piccolo"

"Narrator: Ernest Hemingway once said "Every true story ends in death." Well, this is a true story."

"James Caan - Brian Piccolo"

"Brian Piccolo died of cancer at the age of 26. He left a wife and three daughters. He also left a great many loving friends who miss and think of him often. But when they think of him, it's not how he died that they remember - but how he lived. How he did live!"

"Jack Warden - Coach George Halas"

"Billy Dee Williams - Gale Sayers"

"Uh, you uh, all know that we hand out a game ball to the outstanding player. Well, I'd like to change that. We just got word that Brian Piccolo is - that's he's sick, very sick. And, uh, it looks, uh, like he might never play football again, or, uh, a long time. And, I think we should dedicate ourselves to, uh, give our maximum effort to win this game and give the game ball to 'Pic'. We can all sign it. And take it up. Aw, sh—Oh, my God."

"[accepting the George S. Halas award] I'd like to tell you about a guy I know, a friend of mine. His name is Brian Piccolo. And he has the heart of a giant, and that rare form of courage that allows him to kid himself and his opponent, cancer. He has a mental attitude that makes me proud to have a friend who spells out the world 'courage,' 24 hours a day, every day of his life. Now you honor me by giving me this award. But I say to you here now Brian Piccolo is the man who deserves the George S. Halas award. It is mine tonight... and Brian Piccolo's tomorrow. I love Brian Piccolo. And I'd like all of you to love him too. And so tonight, when you hit your knees, please ask God to love him."

"Dick Butkus - Himself"

"Ed O'Bradovich - Himself"

"So, Concannon calls this trap play, and it's just beautiful... 43 yards, wasn't it 43? Ah. So, Halas sees he's tired, and sends me in, so I go in, he comes out. Concannon then figures he's gonna get REALLY foxy... you know, Concannon is... So, he says, "Um, same play. VERY SAME PLAY." Now, a trap play is also called, a SUCKER play, because it makes the defense look REAL bad when it works. Now, defenses DO NOT like to look real bad, see... it makes 'em kinda surly... So, anyway, all the linemen go this way, and it's like I am lookin' at a team portrait of the Los Angeles Rams! "Hey, Deacon! Merlin! How's the family, Rosey?""

"Judy Pace - Linda Sayers"

"Bernie Casey - J.C. Caroline"

"Renée Zellweger as Ellen Gulden"

"William Hurt as George Gulden"

"Tom Everett Scott as Brian Gulden"

"Your mother needs you, Ellen! Jesus Christ, you've got a Harvard education, but where is your heart?"

"It's so much easier to be happy. It's so much easier to choose to love the things that you have, instead of always yearning for what you're missing, or what it is that you're imagining you're missing. It is so much more peaceful."

"Lauren Graham as Jules"

"Meryl Streep as Kate Gulden"

"Julianne Nicholson as College student"

"Patrick Breen as Mr. Tweedy"

"Nicky Katt as Jordan Belzer"

"James Eckhouse as District Attorney"

"Gerrit Graham as Oliver Most"

"He was a doctor who thought he knew it all... until he became a patient."

"If I ever hear you describe a patient as "terminal" again, that's how you'll describe your career!"

"An Uplifting Story About Finding New Meaning In Life."

"I've always wanted to slit your throat, and now I get a chance to."

"I pray. I meditate. I eat chocolate. I dance."

"[regarding Dr. Blumfield, who believes unconscious patients can still hear] Where E.N.T. meets E.S.P.!"

"[to Dr. MacKee] I am the doctor and you are the patient and I am telling you when I am available."

"[to Aurora] Momma, that's the first time I stopped hugging first. I like that."

"[to Flap] Raising three children, working full-time, and chasing women requires a lot more energy than you have. You know, one of the nicest qualities about you has always been that you recognized your weaknesses. Don't lose that quality now just when you need it the most."