Lopez vs Lopez

"George Lopez as George"

"Mayan Lopez as Mayan, George's Daughter"

"Noelle the Rescue Dog as Churro, The Family Dog"

"Matt Shively as Quinten Van Bryan, Mayan's Boyfriend"

"Brice Gonzalez as Chance Lopez, George's grandson and Mayan's and Quinten's son"

"Selenis Leyva as Rosie, George's ex-wife"

"Al Madrigal as Oscar, an employee of George's who is frequently stoned"

"Laci Mosley as Brookie, Mayan's co-worker at the vet's office"

"Aparna Nancherla as Dr. Pocha, a veterinarian and Mayan's Boss"

"Caroline Rhea as Jana, a pushy rich Lady customer"

"Liz Torres as Daisy, Rosie's Grandma and Sister"

"Stephen Tobolowsky as Sam Van Bryan, Quiten's Father"

"Momo Rodriguez as Momo, one of George's employees"

"Cheech Marin as Carlos (Guest Star: Season 1, Recurring: Season 2)"

"Jaime Camil as Josue Consuelos (Season 2)"

"Moises Chavez as Raul (Guest Star: Season 1, Recurring: Season 2)"

"Jerry Garcia as Mando"

"Adam Kulbersh as Jerry"

"Maria Canals-Barrera as Lily' Rosie's Sister"

"Ana Rey as Flor, Rosie's Sister"

"Nathan Miranda as Robbie"

"Constance Marie as Connie"

"Valente Rodriguez as Val"

"Belita Moreno as Bella"

"Luis Armand Garcia as Louie"

"Rita Moreno as Dolores Lopez, George's Grandma"

"Michelle Ortiz as Mrs. Garcia"

"Neil Flynn as Steve"

"Eden Sher as June"

"Kensie Mills as Paloma"

"Jacob Vargas as Javier"

"Harvey Guillen as Miguel"

"Jessica Marie Garcia as Yesika"

"Chelsea Rendon as Luna"

"Gregg Sulkin as Dr. Bell"

"Justina Machado as Beatrice 'Bunny' Perez"

"Lidia Porto as Gina"

"Erik Griffin as Don, Mayan's Ex-Godfather"

"Marilyn Milan as Judge Justicia"

"Jesus Zapien as Mr. Reyes"

"Danny Trejo as Danny Martinez"

"Julie Wittner as Jenny"

"Melissa Fumero as Natalia"

"Snoop Dogg as Calvin, George's New Sponser"

"Gabriel Iglesias as Iggy"

"Diana-Maria Riva as Olga"

"Marshawn Lynch as Marshawn"

"Tommy Chong as Bryan"

"Lisa Rinna as Lisa, George's Client"

"Scheana Shay as Erica"