"Prof. Michael Foster has somewhere said that ‘hypothesis is the salt of science.’ Without hypothesis there is no possibility of fruitful investigation. But it is equally true that where the desire to prove a particular hypothesis is dominant, hypothesis becomes the poison of science. The Aryan race theory of Western scholars is as good an illustration of how hypothesis can be the poison of science as one can think of."

"The functional validity of a working hypothesis is not a priori certain, because often it is initially based on intuition. However, logical deductions from such a hypothesis provide expectations (so called prognoses) as to the circumstances under which certain phenomena will appear in nature. Such a postulate or working hypothesis can then be substantiated by additional observations or by experiments especially arranged to test details. The value of the hypothesis is strengthened if the observed facts fit the expectation within the limits of permissible error."

"One thinker no less brilliant than the heresiarch himself, but in the orthodox tradition, advanced a most daring hypothesis. This felicitous supposition declared that there is only one Individual, and that this indivisible Individual is every one of the separate beings in the universe, and that these beings are the instruments and masks of divinity itself."

"There are two possible outcomes: if the result confirms the hypothesis, then you've made a measurement. If the result is contrary to the hypothesis, then you've made a discovery."

"It is human nature to avoid being consumed by hypotheticals until they are staring us squarely in the face."

"I do not yet want to form a hypothesis to test, because as soon as you make a hypothesis, you become prejudiced. Your mind slides into a groove, and once it is in that groove, has difficulty noticing anything outside of it. During this time, my sense must be sharp; that is the main thing — to be sharp, yet open."

"Now all hypotheses, by definition, involve make-believe. Many of them...involve sort-crossing, and are therefore metaphors. The conclusion ... is to try to adopt the actual technique of Plato...Then, whether we suppose that man is a state, or that the world is a machine, or that man is a wolf, the risk of confusing the facts of one sort with those of the other will be lessened."

"The truth is, that these writings of mine were meant to protect the arguments of Parmenides against those who make fun of him and seek to show the many ridiculous and contradictory results which they suppose to follow from the affirmation of the one. My answer is addressed to the partisans of the many, whose attack I return with interest by retorting upon them that their hypothesis of the being of many, if carried out, appears to be still more ridiculous than the hypothesis of the being of one. Zeal for my master led me to write the book in the days of my youth, but some one stole the copy; and therefore I had no choice whether it should be published or not; the motive, however, of writing, was not the ambition of an elder man, but the pugnacity of a young one."