biologists-from-canada

"I got to see life under the microscope at an early age."

"[The Biophysical Journal] is one of the few journals with the aim of helping authors to improve their papers, rather than just rejecting most of them."

"It was a challenge to find a permanent job in the 1980s"

"None of Avery's former colleagues have been able to explain his extraordinary success in training young scientists. Even though his research group was never very large, a remarkable number of those who passed through his laboratory emerged as leaders in medical microbiology."

"In view of the fact that lobar pneumonia is prevalent in military camps in the United States, and that at present it is impossible to obtain white mice in sufficient numbers for carrying out the biologic tests necessary in the determination of types of pneumococcus, a rapid cultural method dispensing with the use of these animals is now proposed."

"The reports of various observers indicate that great difference of opinion exists concerning the etiologic significance of B. influenza in the present epidemic of influenza. Some investigators have been able to isolate this organism from a large percentage of the cases that they have observed; others have succeeded in recovering it in very few instances. It is possible that technical difficulties in the isolation and growth of this microorganism may be in part responsible for the discordant results obtained in different laboratories."

"At Colgate University he tied for first prize in an oratory contest with classmate Harry Emerson Fosdick ... Avery also played cornet well enough to have performed in concert with the National Conservatory of Music—a concert conducted by Antonin Dvořák—and he often drew ink caricatures and painted landscapes."

"My journey to become a polar specialist, photographing, specializing in the polar regions, began when I was four years old, when my family moved from southern Canada to Northern Baffin Island, up by Greenland. There we lived with the Inuit in the tiny Inuit community of 200 Inuit people, where [we] were one of three non-Inuit families. And in this community, we didn't have a television; we didn't have computers, obviously, radio. We didn't even have a telephone. All of my time was spent outside with the Inuit, playing. The snow and the ice were my sandbox, and the Inuit were my teachers. And that's where I became truly obsessed with this polar realm. And I knew someday that I was going to do something that had to do with trying to share news about it and protect it."

"If the vapid writings . . . did indeed emanate from him, I can only say that this implies a terrible post-mortem reduction of personal capacities. (Survival of death with such an appalling decay of personality makes it, at least to me, a rather unattractive prospect.)"

"It is necessary to study not only parts and processes in isolation, but also to solve the decisive problems found in organization and order unifying them, resulting from dynamic interaction of parts, and making the the behavior of the parts different when studied in isolation or within the whole."

"Systems thinking plays a dominant role in a wide range of fields from industrial enterprise and armaments to esoteric topics of pure science. Innumerable publications, conferences, symposia and courses are devoted to it. Professions and jobs have appeared in recent years which, unknown a short while ago, go under names such as systems design, systems analysis, systems engineering and others."

"Another recent development is the theory of formal organizations, that is, structures planfully instituted, such as those of an army, Bureaucracy, business enterprise, etc. This theory is framed in a philosophy which accepts the premise that the only meaningful way to study organization is to study it as a system."

"The system problem is essentially the problem of the limitation of analytical procedures in science. This used to be expressed by half-metaphysical statements, such as emergent evolution or ‘the whole is more than the sum of its parts,’ but has a clear operational meaning."

"Modern science is characterized by its ever-increasing specialization, necessitated by the enormous amount of data, the complexity of techniques and of theoretical structures within every field. Thus science is split into innumerable disciplines continually generating new subdisciplines. In consequence, the physicist, the biologist, the psychologist and the social scientist are, so to speak, encapsulated in their private universes, and it is difficult to get word from one cocoon to the other."

"Thus, there exist models, principles, and laws that apply to generalized systems or their subclasses, irrespective of their particular kind, the nature of their component elements, and the relations or „forces‟ between them. It seems legitimate to ask for a theory, not of systems of a more or less special kind, but of universal principles applying to systems in general. In this way, we postulate a new discipline called General Systems Theory. Its subject matter is the formulation and derivation of those principles, which are valid for „systems‟ in general."

"Apparently, the isomorphisms of laws rest in our cognition on the one hand, and in reality on the other."

"Every organism represents a system, by which term we mean a complex of elements in mutual interaction. From this obvious statement the limitations of the analytical and summative conceptions must follow. First, it is impossible to resolve the phenomena of life completely into elementary units; for each individual part and each individual event depends not only on conditions within itself, but also to a greater or lesser extent on the conditions within the whole, or within superordinate units of which it is a part. Hence the behavior of an isolated part is, in general, different from its behavior within the context of the whole... Secondly, the actual whole shows properties that are absent from its isolated parts."

"Unsere Aufgabe muß es vielmehr sein, die Lebewesen als Systeme besonderer Art von in dynamischer Wechselwirkung stehenden Elementen zu betrachten und die hier geltenden Systemgesetze zu ermitteln, welche die Ordnung aller Teile und Vorgänge untereinander beherrschen. Notwendig ist sowohl die Untersuchung der Teile und Vorgänge als auch der Beziehungen, in denen diese zueinander und zum Ganzen stehen."

"The characteristic of the organism is first that it is more than the sum of its parts and second that the single processes are ordered for the maintenance of the whole."

"From the methodological standpoint, however, we see that 'mechanism' and 'vitalism' by no means form the mutually exclusive disjunction they have been supposed to do. If a 'non-mechanist' wishes to deny the assumption of methodological mechanism that biological explanations must also be physico-chemical ones, it is obviously by no means intended that the required explanation must be 'vitalistic', i.e. involving the assumption that in living organisms factors analogous to psychical ones are 'at work'. A 'non-mechanistic' theory which is not all 'vitalistic' thus appears to be logically possible, and if we make a critical study of mechanism and vitalism this possibility will be seen to be of special importance."

"From the physical point of view the characteristic state of the living organism is that of an open system. A system is closed if no material enters or leaves it; it is open if there is import and export and, therefore, change of the components. Living systems are open systems, maintaining themselves in exchange of materials with environment, and in continuous building up and breaking down of their components."

"What we call growth of even a simple organism is a tremendously complex phenomenon from the biochemical, physiological, cytological, and morphological viewpoints."

"We are confronted with problems of organized complexity... organization runs through all levels of reality and science."

"There are correspondences in the principles which govern the behavior of entities that are intrinsically widely different. These correspondences are due to the fact that they all can be considered, in certain aspects, "systems," that is, complexes of elements standing in interaction. [It seems] that a general theory of systems would be a useful tool providing, on the one hand, models that can be used in, and transferred to, different fields, and safeguarding, on the other hand, from vague analogies which often have marred the progress in these fields."

"We are seeking for another basic outlook - the world as organization. This would profoundly change the categories of our thinking and influence our practical attitudes. We must envision the biosphere as a whole with mutually reinforcing or mutually destructive interdependencies."

"(a) There is a general tendency towards integration in the various sciences, natural and social. (b) Such integration seems to be centered in a general theory of systems. (c) Such theory may be an important means of aiming at exact theory in the nonphysical fields of science. (d) Developing unifying principles running "vertically" through the universe of the individual sciences, this theory brings us nearer to the goal of the unity of sciences. (e) This can lead to a much needed integration in scientific education."

"General systems theory (in the narrow sense of the term) is a discipline concerned with the general properties and laws of “systems”. A system is defined as a complex of components in interaction, or by some similar proposition. Systems theory tries to develop those principles that apply to systems in general, irrespective of the nature of the system, of their components, and of the relations or “forces” between them. The system components need not even be material, as, for example, in the system analysis of a commercial enterprise where components such as buildings, machines, personnel, money and “good will” of customers enter."

"If someone were to analyze current notions and fashionable catchwords, he would find "systems" high on the list. The concept has pervaded all fields of science and penetrated into popular thinking, jargon and mass media."

"Classical science in its diverse disciplines, be it chemistry, biology, psychology or the social sciences, tried to isolate the elements of the observed universe - chemical compounds and enzymes, cells, elementary sensations, freely competing individuals, what not -- expecting that, by putting them together again, conceptually or experimentally, the whole or system - cell, mind, society - would result and be intelligible. Now we have learned that for an understanding not only the elements but their interrelations as well are required: say, the interplay of enzymes in a cell, of many mental processes conscious and unconscious, the structure and dynamics of social systems and the like."

"Higher, directed forms of energy (e.g., mechanical, electric, chemical) are dissipated, that is, progressively converted into the lowest form of energy, i.e., undirected heat movement of molecules; chemical systems tend toward equilibria with maximum entropy; machines wear out owing to friction; in communication channels, information can only be lost by conversion of messages into noise but not vice versa, and so forth."

"From the statements we have made, a stupendous perspective emerges, a vista towards a hitherto unsuspected unity of the conception of the world. Similar general principles have evolved everywhere, whether we are dealing with inanimate things, organisms, mental or social processes. What is the origin of these correspondences? We answer this question by the claim for a new realm of science, which we call General System Theory. It is a logico-mathematical field, the subject matter of which is the formulation and derivation of those principles which hold for systems in general. A "system" can be defined as a complex of elements standing in interaction. There are general principles holding for systems, irrespective of the nature of the component elements and of the relations or forces between them."

"You cannot sum up the behavior of the whole from the isolated parts, and you have to take into account the relations between the various subordinate systems which are super-ordinated to them in order to understand the behavior of the parts."

"While we can conceive of a sum [or aggregate] as being composed gradually, a system as a total of parts with its [multiplicative] interrelations has to be conceived of as being composed instantly."

"Teleologie ist … ein Ausfluss der Systemgesetzlichkeit und damit ein legitimer Gegenstand naturwissenschaftlicher Forschung"

"A system can be defined as a set of elements standing in interrelations. Interrelation means that elements, p, stand in relations, R, so that the behavior of an element p in R is different from its behavior in another relation, R’. If the behaviors in R and R’ are not different, there is no interaction, and the elements behave independently with respect to the relations R and R’."

"Progress is only possible by passing from a state of undifferentiated wholeness to differentiation of parts."

"What in the whole denotes a causal equilibrium process, appears for the part as a teleological event."

"Our conception is that of a theory about the system in an inertial state... if the organism is a system in an inertial state, as our law expresses it, the metabolic processes generally have to follow the established system; the ever progressing findings must replace the general expression of 'a system in an inertial state' by a more and more detailed knowing about the nature of this system and its chemical, osmotic, fermentive system conditions."

"The rule is derived inductively from experience, therefore does not have any inner necessity, is always valid only for special cases and can anytime be refuted by opposite facts. On the contrary, the law is a logical relation between conceptual constructions; it is therefore deductible from upper [übergeordnete] laws and enables the derivation of lower laws; it has as such a logical necessity in concordance with its upper premises; it is not a mere statement of probability, but has a compelling, apodictic logical value once its premises are accepted"

"Wholeness [Ganzheit], Gestalt, is the primary attribute of life."

"The science of life has nowadays to a certain extent become a crossroad, in which the contemporary intellectual developments converge. The biological theories have acquired a tremendous ideological [weltanschauliche], yes even public and political significance... The condition of biology, problematic in many respects, has led to the situation that the “philosophies of life” were until now by no means satisfactory from the scientific as much as the practical point of view; we see all the more clearly the importance of the theoretical clarification of biology."

"The characteristic of life does not lie in a distinctiveness of single life processes. [Lebensvorgänge], but rather in a certain order among all the processes."

"Mechanism... provides us with no grasp of the specific characteristics of organisms, of the organization of organic processes among one another, of organic 'wholeness', of the problem of the origin of organic 'teleology', or of the historical character of organisms... We must therefore try to establish a new standpoint which — as opposed to mechanism — takes account of organic wholeness, but... treats it in a manner which admits of scientific investigation."

"Animal growth can be considered as a result of a counteraction of synthesis and destruction, of the anabolism and catabolism of the building materials of the body. There will be growth so long as building up prevails over breaking down."

"General Systems Theory... possibly the model of the world as a great organization can help to reinforce the sense of reverence for the living which we have almost lost."

"Today our main problem is that of organized complexity. Concepts like those of organization, wholeness, directiveness, teleology, control, self-regulation, differentiation and the like are alien to conventional physics. However, they pop up everywhere in the biological, behavioural and social sciences, and are, in fact, indispensable for dealing with living organisms or social groups. Thus, a basic problem posed to modern science is a general theory of organization."

"Biological communities are systems of interacting components and thus display characteristic properties of systems, such as mutual interdependence, self-regulation, adaptation to disturbances, approach to states of equilibrium, etc."

"Concepts like those of organization, wholeness, directiveness, teleology, control, self-regulation, differentiation, and the like are alien to conventional science. However, they pop up everywhere in the biological, behavioral, and social sciences and are, in fact, indispensable for dealing with living organisms or social groups. Thus, a basic problem posed to modem science is a general theory of organization. General Systems Theory is, in principle, capable of giving exact definitions for such concepts."

"Scientists, operating in the various disciplines, are encapsulated in their private universe, and it is difficult to get word from one cocoon to the other."

"Major aims of general theory: (1) There is a general tendency toward integration in the various sciences, natural and social. (2) Such integration seems to be centered in a general theory of systems. (3) Such theory may be an important means for aiming at exact theory in the nonphysical fields of science. (4) Developing unifying principles running "vertically" through the universe of the individual sciences, this theory brings us nearer the goal of the unity of science. (5) This can lead to a much-needed integration in scientific education."