Scientists from Boston

"The pioneer spirit is still vigorous within this nation. Science offers a largely unexplored hinterland for the pioneer who has the tools for his task. The rewards of such exploration both for the Nation and the individual are great. Scientific progress is one essential key to our security as a nation, to our better health, to more jobs, to higher standard of living, and to our cultural progress."

"As long as scientists are free to pursue the truth wherever it may lead, there will be a flow of new scientific knowledge to those who can apply it to practical problems."

"This has not been a scientist's war; it has been a war in which all have had a part. The scientists, burying their old professional competition in the demand of a common cause, have shared greatly and learned much. It has been exhilarating to work in effective partnership. Now, for many, this appears to be approaching an end. What are the scientists to do next?"

"There is a growing mountain of research. But there is increased evidence that we are being bogged down today as specialization extends. The investigator is staggered by the findings and conclusions of thousands of other workers — conclusions which he cannot find time to grasp, much less to remember, as they appear. Yet specialization becomes increasingly necessary for progress, and the effort to bridge between disciplines is correspondingly superficial."

"Professionally our methods of transmitting and reviewing the results of research are generations old and by now are totally inadequate for their purpose. If the aggregate time spent in writing scholarly works and in reading them could be evaluated, the ratio between these amounts of time might well be startling. Those who conscientiously attempt to keep abreast of current thought, even in restricted fields, by close and continuous reading might well shy away from an examination calculated to show how much of the previous month's efforts could be produced on call. Mendel's concept of the laws of genetics was lost to the world for a generation because his publication did not reach the few who were capable of grasping and extending it; and this sort of catastrophe is undoubtedly being repeated all about us, as truly significant attainments become lost in the mass of the inconsequential."

"The difficulty seems to be, not so much that we publish unduly in view of the extent and variety of present-day interests, but rather that publication has been extended far beyond our present ability to make real use of the record. The summation of human experience is being expanded at a prodigious rate, and the means we use for threading through the consequent maze to the momentarily important item is the same as was used in the days of square-rigged ships."

"Two centuries ago Leibnitz invented a calculating machine which embodied most of the essential features of recent keyboard devices, but it could not then come into use. The economics of the situation were against it: the labor involved in constructing it, before the days of mass production, exceeded the labor to be saved by its use, since all it could accomplish could be duplicated by sufficient use of pencil and paper. Moreover, it would have been subject to frequent breakdown, so that it could not have been depended upon; for at that time and long after, complexity and unreliability were synonymous."

"Babbage, even with remarkably generous support for his time, could not produce his great arithmetical machine. His idea was sound enough, but construction and maintenance costs were then too heavy. Had a Pharaoh been given detailed and explicit designs of an automobile, and had he understood them completely, it would have taxed the resources of his kingdom to have fashioned the thousands of parts for a single car, and that car would have broken down on the first trip to Giza."

"Machines with interchangeable parts can now be constructed with great economy of effort. In spite of much complexity, they perform reliably. Witness the humble typewriter, or the movie camera, or the automobile."

"A spider web of metal, sealed in a thin glass container, a wire heated to brilliant glow, in short, the thermionic tube of radio sets, is made by the hundred million, tossed about in packages, plugged into sockets — and it works! Its gossamer parts, the precise location and alignment involved in its construction, would have occupied a master craftsman of the guild for months; now it is built for thirty cents. The world has arrived at an age of cheap complex devices of great reliability; and something is bound to come of it."

"A record, if it is to be useful to science, must be continuously extended, it must be stored, and above all it must be consulted."

"The camera hound of the future wears on his forehead a lump a little larger than a walnut. It takes pictures 3 millimeters square, later to be projected or enlarged, which after all involves only a factor of 10 beyond present practice."

"The Encyclopoedia Britannica could be reduced to the volume of a matchbox. A library of a million volumes could be compressed into one end of a desk. If the human race has produced since the invention of movable type a total record, in the form of magazines, newspapers, books, tracts, advertising blurbs, correspondence, having a volume corresponding to a billion books, the whole affair, assembled and compressed, could be lugged off in a moving van. Mere compression, of course, is not enough; one needs not only to make and store a record but also to be able to consult it, and this aspect of the matter comes later. Even the modern great library is not generally consulted; it is nibbled by a few."

"To make the record, we now push a pencil or tap a typewriter. Then comes the process of digestion and correction, followed by an intricate process of typesetting, printing, and distribution. To consider the first stage of the procedure, will the author of the future cease writing by hand or typewriter and talk directly to the record?"

"Much needs to occur, however, between the collection of data and observations, the extraction of parallel material from the existing record, and the final insertion of new material into the general body of the common record. For mature thought there is no mechanical substitute. But creative thought and essentially repetitive thought are very different things. For the latter there are, and may be, powerful mechanical aids."

"Adding a column of figures is a repetitive thought process, and it was long ago properly relegated to the machine. True, the machine is sometimes controlled by the keyboard, and thought of a sort enters in reading the figures and poking the corresponding keys, but even this is avoidable."

"The advanced arithmetical machines of the future will be electrical in nature, and they will perform at 100 times present speeds, or more. Moreover, they will be far more versatile than present commercial machines, so that they may readily be adapted for a wide variety of operations. They will be controlled by a control card or film, they will select their own data and manipulate it in accordance with the instructions thus inserted, they will perform complex arithmetical computations at exceedingly high speeds, and they will record results in such form as to be readily available for distribution or for later further manipulation."

"There will always be plenty of things to compute in the detailed affairs of millions of people doing complicated things."

"Every time one combines and records facts in accordance with established logical processes, the creative aspect of thinking is concerned only with the selection of the data and the process to be employed, and the manipulation thereafter is repetitive in nature and hence a fit matter to be relegated to the machines."

"The needs of business, and the extensive market obviously waiting, assured the advent of mass-produced arithmetical machines just as soon as production methods were sufficiently advanced. With machines for advanced analysis no such situation existed; for there was and is no extensive market; the users of advanced methods of manipulating data are a very small part of the population."

"If scientific reasoning were limited to the logical processes of arithmetic, we should not get far in our understanding of the physical world. One might as well attempt to grasp the game of poker entirely by the use of the mathematics of probability. The abacus, with its beads strung on parallel wires, led the Arabs to positional numeration and the concept of zero many centuries before the rest of the world; and it was a useful tool — so useful that it still exists."

"It is a far cry from the abacus to the modern keyboard accounting machine. It will be an equal step to the arithmetical machine of the future. But even this new machine will not take the scientist where he needs to go. Relief must be secured from laborious detailed manipulation of higher mathematics as well, if the users of it are to free their brains for something more than repetitive detailed transformations in accordance with established rules."

"A mathematician is not a man who can readily manipulate figures; often he cannot. He is not even a man who can readily perform the transformation of equations by the use of calculus. He is primarily an individual who is skilled in the use of symbolic logic on a high plane, and especially he is a man of intuitive judgment in the choice of the manipulative processes he employs."

"Whenever logical processes of thought are employed — that is, whenever thought for a time runs along an accepted groove — there is an opportunity for the machine. Formal logic used to be a keen instrument in the hands of the teacher in his trying of students' souls. It is readily possible to construct a machine which will manipulate premises in accordance with formal logic, simply by the clever use of relay circuits. Put a set of premises into such a device and turn the crank, and it will readily pass out conclusion after conclusion, all in accordance with logical law, and with no more slips than would be expected of a keyboard adding machine."

"There may be millions of fine thoughts, and the account of the experience on which they are based, all encased within stone walls of acceptable architectural form; but if the scholar can get at only one a week by diligent search, his syntheses are not likely to keep up with the current scene."

"There is another form of selection best illustrated by the automatic telephone exchange. You dial a number and the machine selects and connects just one of a million possible stations. It does not run over them all. It pays attention only to a class given by a first digit, and so on; and thus proceeds rapidly and almost unerringly to the selected station."

"To be able to key one sheet of a million before an operator in a second or two, with the possibility of then adding notes thereto, is suggestive in many ways. It might even be of use in libraries, but that is another story. At any rate, there are now some interesting combinations possible. One might, for example, speak to a microphone, in the manner described in connection with the speech-controlled typewriter, and thus make his selections. It would certainly beat the usual file clerk."

"Our ineptitude in getting at the record is largely caused by the artificiality of systems of indexing. When data of any sort are placed in storage, they are filed alphabetically or numerically, and information is found (when it is) by tracing it down from subclass to subclass. It can be in only one place, unless duplicates are used; one has to have rules as to which path will locate it, and the rules are cumbersome. Having found one item, moreover, one has to emerge from the system and re-enter on a new path. The human mind does not work that way. It operates by association. With one item in its grasp, it snaps instantly to the next that is suggested by the association of thoughts, in accordance with some intricate web of trails carried by the cells of the brain. It has other characteristics, of course; trails that are not frequently followed are prone to fade, items are not fully permanent, memory is transitory. Yet the speed of action, the intricacy of trails, the detail of mental pictures, is awe-inspiring beyond all else in nature."

"Consider a future device for individual use, which is a sort of mechanized private file and library. It needs a name, and to coin one at random, memex will do. A memex is a device in which an individual stores all his books, records, and communications, and which is mechanized so that it may be consulted with exceeding speed and flexibility. It is an enlarged intimate supplement to his memory. It consists of a desk, and while it can presumably be operated from a distance, it is primarily the piece of furniture at which he works. On the top are slanting translucent screens, on which material can be projected for convenient reading. There is a keyboard, and sets of buttons and levers. Otherwise it looks like an ordinary desk."

"Only a small part of the interior of the memex is devoted to storage, the rest to mechanism. Yet if the user inserted 5000 pages of material a day it would take him hundreds of years to fill the repository, so he can be profligate and enter material freely."

"Most of the memex contents are purchased on microfilm ready for insertion. Books of all sorts, pictures, current periodicals, newspapers, are thus obtained and dropped into place. Business correspondence takes the same path. And there is provision for direct entry."

"There is, of course, provision for consultation of the record by the usual scheme of indexing. If the user wishes to consult a certain book, he taps its code on the keyboard, and the title page of the book promptly appears before him, projected onto one of his viewing positions."

"A special button transfers him immediately to the first page of the index. Any given book of his library can thus be called up and consulted with far greater facility than if it were taken from a shelf. As he has several projection positions, he can leave one item in position while he calls up another."

"All this is conventional, except for the projection forward of present-day mechanisms and gadgetry. It affords an immediate step, however, to associative indexing, the basic idea of which is a provision whereby any item may be caused at will to select immediately and automatically another. This is the essential feature of the memex. The process of tying two items together is the important thing."

"Wholly new forms of encyclopedias will appear, ready-made with a mesh of associative trails running through them, ready to be dropped into the memex and there amplified. The lawyer has at his touch the associated opinions and decisions of his whole experience, and of the experience of friends and authorities. The patent attorney has on call the millions of issued patents, with familiar trails to every point of his client's interest. The physician, puzzled by its patient's reactions, strikes the trail established in studying an earlier similar case, and runs rapidly through analogous case histories, with side references to the classics for the pertinent anatomy and histology. The chemist, struggling with the synthesis of an organic compound, has all the chemical literature before him in his laboratory, with trails following the analogies of compounds, and side trails to their physical and chemical behavior."

"The historian, with a vast chronological account of a people, parallels it with a skip trail which stops only at the salient items, and can follow at any time contemporary trails which lead him all over civilization at a particular epoch. There is a new profession of trail blazers, those who find delight in the task of establishing useful trails through the enormous mass of the common record. The inheritance from the master becomes, not only his additions to the world's record, but for his disciples the entire scaffolding by which they were erected."

"Thus science may implement the ways in which man produces, stores, and consults the record of the race. It might be striking to outline the instrumentalities of the future more spectacularly, rather than to stick closely to the methods and elements now known and undergoing rapid development, as has been done here. Technical difficulties of all sorts have been ignored, certainly, but also ignored are means as yet unknown which may come any day to accelerate technical progress as violently as did the advent of the thermionic tube."

"All our steps in creating or absorbing material of the record proceed through one of the senses — the tactile when we touch keys, the oral when we speak or listen, the visual when we read. Is it not possible that some day the path may be established more directly?"

"The impulses which flow in the arm nerves of a typist convey to her fingers the translated information which reaches her eye or ear, in order that the fingers may be caused to strike the proper keys. Might not these currents be intercepted, either in the original form in which information is conveyed to the brain, or in the marvelously metamorphosed form in which they then proceed to the hand?"

"In the outside world, all forms of intelligence, whether of sound or sight, have been reduced to the form of varying currents in an electric circuit in order that they may be transmitted. Inside the human frame exactly the same sort of process occurs. Must we always transform to mechanical movements in order to proceed from one electrical phenomenon to another? It is a suggestive thought, but it hardly warrants prediction without losing touch with reality and immediateness."

"Presumably man's spirit should be elevated if he can better review his shady past and analyze more completely and objectively his present problems. He has built a civilization so complex that he needs to mechanize his record more fully if he is to push his experiment to its logical conclusion and not merely become bogged down part way there by overtaxing his limited memory. His excursion may be more enjoyable if he can reacquire the privilege of forgetting the manifold things he does not need to have immediately at hand, with some assurance that he can find them again if they prove important."

"The applications of science have built man a well-supplied house, and are teaching him to live healthily therein. They have enabled him to throw masses of people against another with cruel weapons. They may yet allow him truly to encompass the great record and to grow in the wisdom of race experience. He may perish in conflict before he learns to wield that record for his true good. Yet, in the application of science to the needs and desires of man, it would seem to be a singularly unfortunate stage at which to terminate the process, or to lose hope as to the outcome."

"Science can be effective in the national welfare only as a member of a team, whether the conditions be peace or war. But without scientific progress no amount of achievement in other directions can insure our health, prosperity, and security as a nation in the modern world."

"The responsibility for the creation of new scientific knowledge — and for most of its application — rests on that small body of men and women who understand the fundamental laws of nature and are skilled in the techniques of scientific research. We shall have rapid or slow advance on any scientific frontier depending on the number of highly qualified and trained scientists exploring it."

"On the wisdom with which we bring science to bear in the war against disease, in the creation of new industries, and in the strengthening of our Armed Forces depends in large measure our future as a nation."

"Advances in science when put to practical use mean more jobs, higher wages, shorter hours, more abundant crops, more leisure for recreation, for study, for learning how to live without the deadening drudgery which has been the burden of the common man for ages past. Advances in science will also bring higher standards of living, will lead to the prevention or cure of diseases, will promote conservation of our limited national resources, and will assure means of defense against aggression. But to achieve these objectives — to secure a high level of employment, to maintain a position of world leadership — the flow of new scientific knowledge must be both continuous and substantial."

"Science, by itself, provides no panacea for individual, social, and economic ills. It can be effective in the national welfare only as a member of a team, whether the conditions be peace or war. But without scientific progress no amount of achievement in other directions can insure our health, prosperity, and security as a nation in the modern world."

"The publicly and privately supported colleges, universities, and research institutes are the centers of basic research. They are the wellsprings of knowledge and understanding. As long as they are vigorous and healthy and their scientists are free to pursue the truth wherever it may lead, there will be a flow of new scientific knowledge to those who can apply it to practical problems in Government, in industry, or elsewhere."

"Scientific progress on a broad front results from the free play of free intellects, working on subjects of their own choice, in the manner dictated by their curiosity for exploration of the unknown. Freedom of inquiry must be preserved under any plan for Government support of science..."

"We puzzle as to whether the universe is bounded or extends forever; whether, indeed, it may only be one universe among many. We speculate as to whether our universe began in a vast explosion, whether it pulsates between utter compression and wide diffusion, whether it is self-renewing and thus unchanged forever. And we are humble. But science teaches more than this. It continually reminds us that we are still ignorant and there is much to learn. Time and space are interconnected in strange ways; there is no absolute simultaneity. Within the atom occur phenomena concerning which visualization is futile, to which common sense, the guidance from our everyday experience, has no application, which yield to studies by equations that have no meaning except that they work. Mass and energy transform one into another, Gravitation, the solid rock on which Newton built, may be merely a property of the geometry of the cosmos. Life, as its details unfold before us, becomes ever more intricate, emphasizing more and more our wonder that its marvelous functioning could have been produced by chance and time. The human mind, merely in its chemical and physical aspects, takes on new inspiring attributes. And what is the conclusion? He who follows science blindly, and who follows it alone, comes to a barrier beyond which he cannot see. He who would tell us with the authority of scholarship a complete story of why we exist, of our mission here, has a duty to speak convincingly in a world where men increasingly think for themselves. Exhortation needs to be revised, not to weaken its power, but to increase it, for men who are no longer in the third century. As this occurs, and on the essential and central core of faith, science will of necessity be silent. But its silence will be the silence of humility, not the silence of disdain. A belief may be larger than a fact. A faith that is overdefined is the very faith most likely to prove inadequate to the great moments of life."

"It is Earlier Than We Think."

"Science has a simple faith, which transcends utility. Nearly all men of science, all men of learning for that matter, and men of simple ways too, have it in some form and in some degree. It is the faith that it is the privilege of man to learn to understand, and that this is his mission. If we abandon that mission under stress we shall abandon it forever, for stress will not cease. Knowledge for the sake of understanding, not merely to prevail, that is the essence of our being. None can define its limits, or set its ultimate boundaries."

"That the threat is now intense is not a reason to abandon our quest for knowledge. It is a reason to hold it more tightly, in spite of the need for action to preserve our freedom, in spite of the distractions of living in turmoil, that it may not be lost or brushed aside by the demands of the hour. We would not neglect our duty to our country and our fellows to strive mightily to preserve our ways and our lives. There is an added duty, not inconsistent, not less. It is the duty to so live that there may be a reason for living, beyond the mere mechanisms of life. It is the duty to carry on, under stress, the search for understanding."

"Bush is responsible for the whole architecture of government support for science. Today, everyone thinks these terrific innovations came from the minds of bright kids, but they don't realize that these kids needed an environment to be in. It came from Bush. He said, "Give these people money, let them play, and they'll come up with something.""

"Vannevar Bush is a great name for playing six degrees of separation. Turn back the clock on any aspect of information technology — from the birth of Silicon Valley and the marriage of science and the military to the advent of the World Wide Web — and you find his footprints. As historian Michael Sherry says, "To understand the world of Bill Gates and Bill Clinton, start with understanding Vannevar Bush.""

"[Duesberg] is absolutely correct in saying that no one has proven that AIDS is caused by the AIDS virus. And he is absolutely correct that the virus cultured in the laboratory may not be the cause of AIDS."

"The community as a whole doesn't listen patiently to critics who adopt alternative viewpoints. Although the great lesson of history is that knowledge develops through the conflict of viewpoints. If you simply have a consensus, it generally stultifies. It fails to see the problems of that consensus and it depends on the existence of critics to break up that iceberg and permit knowledge to develop. This is in fact one of the underpinnings of democratic theory. It is one of the reasons why we believe in notions of free speech and it's one of the great forces in terms of intellectual development."

"I would not be surprised if there were another cause of AIDS and even that HIV is not involved."

"I am afraid that those comments go back to the late 80's. At that time I was a skeptic — the argument based on Koch's postulates to try to distinguish between cause and association. … Today I would regard the success of the many antiviral agents which lower the virus titers (to be expected) and also resolve the failure of the immune system (only expected if the virus is the cause of the failure) as a reasonable proof of the causation argument"

"Are physical forces alone at work there, or has evolution begotten something more complex, something not unakin to what we know on Earth as life?"

"The whole object of science is to synthesize, and so simplify; and did we but know the uttermost of a subject we could make it singularly clear."

"Formulae are the anaesthetics of thought, not its stimulants and to make any one think is far better worth while than cramming him with ill-considered, and therefore indigestible, learning."

"That Mars is inhabited by beings of some sort or other we may consider as certain as it is uncertain what these beings may be."

"War is a survival among us from savage times and affects now chiefly the boyish and unthinking element of the nation. The wisest realize that there are better ways for practicing heroism and other and more certain ends of insuring the survival of the fittest. It is something a people outgrow. But whether they consciously practice peace or not, nature in its evolution eventually practices it for them, and after enough of the inhabitants of a globe have killed each other off, the remainder must find it more advantageous to work together for the common good."

"So far as thought may peer into the past, the epic of our solar system began with a great catastrophe. Two suns met. What had been, ceased; what was to be, arose. Fatal to both progenitors, the event dated a stupendous cosmic birth."

"In the great desert of northern Arizona the traveller, threading his way across a sage-brush and cacti plain shut in by abrupt-sided shelves of land rising here and there some hundreds of feet higher, suddenly comes upon a petrified forest."

"In 1936 the notion of a computable function was clarified by Turing, and he showed the existence of universal computers that, with an appropriate program, could compute anything computed by any other computer. [...] In some subconscious sense even the sales departments of computer manufacturers are aware of this, and they do not advertise magic instructions that cannot be simulated on competitors machines, but only that their machines are faster, cheaper, have more memory, or are easier to program."

"Intelligence has two parts, which we shall call the epistemological and the heuristic. The epistemological part is the representation of the world in such a form that the solution of problems follows from the facts expressed in the representation. The heuristic part is the mechanism that on the basis of the information solves the problem and decides what to do. [...] The right way to think about the general problems of metaphysics and epistemology is not to attempt to clear one's own mind of all knowledge and start with 'Cogito ergo sum' and build up from there. Instead, we propose to use all of our knowledge to construct a computer program that knows. The correctness of our philosophical system will be tested by numerous comparisons between the beliefs of the program and our own observations and knowledge."

"[This] is or should be our main scientific activity — studying the structure of information and the structure of problem solving processes independently of applications and independently of its realization in animals or humans."

"LISP is now the second oldest programming language in present widespread use (after FORTRAN)... Its core occupies some kind of local optimum in the space of programming languages given that static friction discourages purely notational changes. Recursive use of conditional expressions, representation of symbolic information externally by lists and internally by list structure, and representation of program in the same way will probably have a very long life."

"One can even conjecture that Lisp owes its survival specifically to the fact that its programs are lists, which everyone, including me, has regarded as a disadvantage."

"Machines as simple as thermostats can be said to have beliefs, and having beliefs seems to be a characteristic of most machines capable of problem solving performance. However, the machines mankind has so far found it useful to construct rarely have beliefs about beliefs, although such beliefs will be needed by computer programs that reason about what knowledge they lack and where to get it. Mental qualities peculiar to human-like motivational structures , such as love and hate, will not be required for intelligent behavior, but we could probably program computers to exhibit them if we wanted to, because our common sense notions about them translate readily into certain program and data structures. Still other mental qualities, e.g. humor and appreciation of beauty, seem much harder to model."

"When we program a computer to make choices intelligently after determining its options, examining their consequences, and deciding which is most favorable or most moral or whatever, we must program it to take an attitude towards its freedom of choice essentially isomorphic to that which a human must take to his own."

"When there's a will to fail, obstacles can be found."

"It's difficult to be rigorous about whether a machine really 'knows', 'thinks', etc., because we're hard put to define these things. We understand human mental processes only slightly better than a fish understands swimming."

"Program designers have a tendency to think of the users as idiots who need to be controlled. They should rather think of their program as a servant, whose master, the user, should be able to control it. If designers and programmers think about the apparent mental qualities that their programs will have, they'll create programs that are easier and pleasanter — more humane — to deal with."

"Whenever we write an axiom, a critic can say that the axiom is true only in a certain context. With a little ingenuity the critic can usually devise a more general context in which the precise form of the axiom doesn't hold. [...] There simply isn't a most general context."

"He who refuses to do arithmetic is doomed to talk nonsense."

"One of the most striking characteristics of this new modification of oxygen is its peculiar odor, and hence Schönbein calls it ozone, from a Greek verb signifying to smell. It frequently happens that a great discovery supplies the wanting links between a number of obscure facts, and thus adds quite as much to our knowledge by its indirect bearings as by the positive additions it makes to the general stock. So it has been with the discovery of ozone. Every one who has used an electrical machine must have noticed the peculiar smell which follows the electrical discharge. This was formerly supposed to be the odor of the electrical fluid itself; but as soon as ozone was discovered, the odor was recognized at once as belonging to this new agent, and it was soon ascertained that electricity is one of the most efficient means of modifying the oxygen of the air."

"A patent is a legal analog of sticky fly paper: it attracts some of the lowest forms of life."

"The world's problems are pressing in on us all. The scale and impact of human activities now affects a great portion of the global resources important to human welfare. These activities are putting growing, often destructive pressure on the global environment, pressure that appears likely to increase as human numbers swell toward the doubling of the world's population that evidently lies ahead. These pressures can spawn or aggravate conflict that. in a world with so much destructive weaponry, generates important national security problems. Great changes are necessary to help ensure a humane future for the generations to come. Most of the world's scientific community and many people in the environmental movement are aware of the gravity of the problems. Yet despite sober warnings from these and other groups, in both the industrial and the developing world, re- medial efforts frequently appear powerless and ineffectual. The scientific community has not taken a sustained, powerful role in the public arena where this great cluster of issues is debated and where the problems must be resolved. There is much more that our community can contribute to assessment, warning, and proposals for new patterns of behavior."

"While science and technology play critical roles in sustaining modern civilization, they are not part of our culture in the sense that they are not commonly studied or well comprehended. Neither the potential nor the limitations of science are understood so that what can be achieved and what is beyond reach are not comprehended. The line between science and magic becomes blurred so that public judgments on technical issues can be erratic or badly flawed. It frequently appears that some people will believe almost anything. Thus judgments can be manipulated or warped by unscrupulous groups. Distortions or outright falsehoods can come to be accepted as fact."

"Distortion and false statements have a sturdy history in public discourse. Neither the government nor large organizations can be depended on to support their objectives honestly and with integrity. Replying in kind turns out not to be an option, not just to retain scientific integrity but for practical reasons. Critics, whether individuals or public interest groups, cannot afford to slant the truth, ever. Scientists are far more vulnerable to the consequences of their own ill-considered words than are laypeople, owing to the care and integrity that is believed to characterize the scientific approach to problems. Intentional distortions are almost always uncovered and the purveyors pilloried without mercy. It may not be forgotten for years and surfaces over and over again. So too will honest mistakes which, along with even minor exaggerations, are seized on and exploited mercilessly. Not a bad rule — one that I and some colleagues observe — is to pull back a bit in most argument. Not only should one never distort nor exaggerate, it is best, I believe, to understate."

"We are immersed in one of the most significant revolutions in man's history. The force that drives this revolution is not social dissension or political ideology, but relentless exploitations of scientific knowledge. There is no prospect that this revolution will subside; on the contrary, it will continue to transform profoundly our modes of living and dying. That many of these transformations have been immeasurably beneficial goes without saying. But, as with all revolutions, the technological revolution has released destructive forces, and our society has failed to cope with them. Thus we have become addicted to an irrational and perilous arms race, and we are unable to protect our natural environment from destruction."

"What should thoughtful people do? Are there means to brighten future prospects in the face of such human myopia and stubbornness? There are many in the scientific community whose views are bleak. One biologist, speaking to me many years ago, remarked that many of his colleagues thought of the behavior of the human race as similar to a one-celled animal's. Such an animal may extend a pseudopod in search of food; if hurt or blocked, it pulls back, but otherwise its activity continues, mindlessly, without understanding, without end. With larger perils unperceived, it can destroy itself."

"All we who can gauge the threats can do is soldier on, exploiting what tools we have, gaining as much ground as time permits: seizing issues when they are ripe, remaining patient and careful with facts, even when faced with relentless and reckless opposition, mounting sustained campaigns and avoiding simple shots across the bow, combining solid analysis with persistent outreach and public education, touching people as widely as we can, and, as Winston Churchill emphasized, never giving up. Many of us in science understand well what the costs of inattention and lack of care will be. … Yet neither we nor others have yet caught the sustained attention of our fellow humans, and, until we do, the world cannot escape from its troubles . Thus the deepest question before us all is: How will our species reach the understanding and gain the political will to alter the prospects on the horizon? No one now has the answer to that need. It is indeed a distant light."

"The horrors of have supplanted the solemnity, the thrilling fascination, of the old unetherized operation upon the human sufferer. Their recorded phenomena, stored away by the physiological inquisitor on dusty shelves, are mostly of as little present use to man as the knowledge of a new comet or of a tungstate of zirconium: perhaps to be confuted the next year, perhaps to remain as fixed truth of immediate value, — contemptibly small compared with the price paid for it in agony and torture."

"Watch the students at a vivisection. It is the blood and suffering, not the science, that rivet their breathless attention. If hospital service makes young students less tender of suffering, vivisection deadens their humanity, and begets indifference to it."

"It should not for a moment be supposed that cultivation of the intellect leads a man to shrink from inflicting pain. Many educated men are no more humane, are in fact far less so, than many comparatively uneducated people."

"There can be no question that the practice of vivisection hardens the sensibility of the operator and begets indifference to the infliction of pain, as well as great carelessness in judging of its severity."

"Every discoverer of a new truth, or inventor of the method which evolves it, makes a dozen, perhaps fifty, useless combinations, experiments, or trials for one successful one. In the realm of electricity or of mechanics there is no objection to this. But when such rejected failures involve a torture of animals, sometimes fearful in its character, there is a distinct objection to it."

"There will come a time when the world will look back to modern vivisection in the name of science as they now do to burning at the stake in the name of religion."

"Anti-cruelty societies should be encouraged. The progress of science has suffered little by their existence, and humanity has gained much."

"The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both."

"As science has penetrated the atom, we’ve discovered that solid matter consists mainly of empty space. We’ve discovered that inert objects, such as rocks, consist of particles whirling round each other trillions of times a second. Likewise, believers and nonbelievers in God may both be right, just traveling the same circle in opposite directions."

"Of course, there have been myriad conceptions of God since the dawn of civilization. There are the Abrahamic conceptions of God, including the monotheistic God of Judaism and the trinitarian God of Christians. In Buddhism, God is almost non-theist. In fact, conceptions of God vary so widely there’s no clear consensus on the definition of God. In short, believers believe God has an incorporeal (immaterial) existence, and that there’s an afterlife...According to biocentrism, a new “theory of everything,” the material and immaterial worlds are co-relative. Life and consciousness represents one side of the equation, matter and energy the other. They can’t be divorced; split them and the reality is gone. Although the current scientific paradigm is based on the belief that the world has an objective observer-independent existence, a long list of experiments shows the opposite."

"Our science fails to recognize those special properties of life that make it fundamental to material reality. This view of the world—biocentrism—revolves around the way a subjective experience, which we call consciousness, relates to a physical process. It is a vast mystery and one that I have pursued my entire life. The conclusions I have drawn place biology above the other sciences in the attempt to solve one of nature’s biggest puzzles, the theory of everything that other disciplines have been pursuing for the last century. Such a theory would unite all known phenomena under one umbrella, furnishing science with an all-encompassing explanation of nature or reality."

"Why do I paint? In my work as a mathematician, form, structure, and economy of expression are important. In music, add tone quality, balance and harmony. And now in painting, these aesthetic values are enhanced by color, contrast, and composition."

"Algebraic geometry has developed in waves, each with its own language and point of view. The late nineteenth century saw the function-theoretic approach of Riemann, the more geometric approach of Brill and Noether, and the purely algebraic approach of Kronecker, Dedekind, and Weber. The Italian school followed with Castelnuovo, Enriques, and Severi, culminating in the classification of algebraic surfaces. Then came the twentieth-century "American" school of Chow, Weil, and Zariski, which gave firm algebraic foundations to the Italian intuition. Most recently, Serre and Grothendieck initiated the French school, which has rewritten the foundations of algebraic geometry in terms of schemes and cohomology, and which has an impressive record of solving old problems with new techniques. Each of these schools has introduced new concepts and methods."

"Doing your own gardening makes you much more aware of food cycles, what it takes to grow it, and what the range of food quality is."

"When it comes to getting away, big pits are a handicap. A quarter-pound seed isn't going to be blown about by anything less than a hurricane, and in water an avocado pit sinks."

"All that we can say, looking at the avocado pit, is that whatever swallowed it must have been big. As big as those fossil skeletons staring out at us from behind the dusty glass of museum cases."

"But why did I do it? I confess that I'm an unabashed Old Leftist who never quite understood how deconstruction was supposed to help the working class. And I'm a stodgy old scientist who believes, naively, that there exists an external world, that there exist objective truths about that world, and that my job is to discover some of them."

"Anyone who believes that the laws of physics are mere social conventions is invited to try transgressing those conventions from the windows of my apartment. (I live on the twenty-first floor.)"

"The results of my little experiment [Sokal affair] demonstrate, at the very least, that some fashionable sectors of the American academic Left have been getting intellectually lazy. The editors of Social Text liked my article because they liked its conclusion: that "the content and methodology of postmodern science provide powerful intellectual support for the progressive political project" [sec. 6]. They apparently felt no need to analyze the quality of the evidence, the cogency of the arguments, or even the relevance of the arguments to the purported conclusion."

"When scientific research is increasingly funded by private corporations that have a financial interest in particular outcomes of that research—is the drug effective or not?—scientific objectivity is undermined. When universities are more interested in patent royalties than in the open sharing of scientific information, the public suffers. There are hundreds of important political and economic issues surrounding science and technology. Sociology of science, at its best, has done much to clarify these issues. But sloppy sociology, like sloppy science, is useless or even counterproductive."

"In southern Florida the orchid flora is more or less confined to the peculiar hammock formations in the Everglades and in the pine woods. In these the species are found on the trees and on the ground, not infrequently around or withing the openings of lime-sinks. Each hammock is apt to have a distinctive flora, and when an orchid is common in one hammock, it may be rare in, or absent from, the next."

"The orchid flora of the Philippine Archipelago is closely allied to that of Celebs, Java, and the Malay Peninsula. There are no endemic genera. The number of endemic species, on the contrary, is very large, at least six-sevenths of the known ones having been found nowhere else. It is safe to say that approximately ninety per cent of the orchid flora is endemic."

"Professor Ames' lineage was one of power and wealth."

"He provides fascinating inside glimpses of Harvard biology in the age of the Olympians—East, Wheeler, Jeffrey, Sargent, Thaxter, Farlow, Weston, Bailey, and "Chinese" Wilson."

"There are great discoveries yet to be made down there, fantastic creatures representing millions of years of evolution and possibly bioactive compounds that could benefit us in ways that we can't even yet imagine. Yet we have spent only a tiny fraction of the money on ocean exploration that we've spent on space exploration. We need a NASA-like organization for ocean exploration, because we need to be exploring and protecting our life support systems here on Earth."

"Maria had a little sheep As pale as rime its hair, And all the places Maria came The sheep did tail her there; In Maria's class it came at last, A sheep can't enter there; It made the children clap their hands, A sheep in class, that's rare."