Nobel laureates in Physiology or Medicine

"The bells which toll for mankind are—most of them, anyway—like the bells of Alpine cattle; they are attached to our own necks, and it must be our fault if they do not make a cheerful and harmonious sound."

"There is no such thing as a Scientific Mind. Scientists are people of very dissimilar temperaments doing different things in very different ways. Among scientists are collectors, classifiers and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. What sort of mind or temperament can all these people be supposed to have in common? Obligative scientists must be very rare, and most people who are in fact scientists could easily have been something else instead."

"The similarity between them is not the taxonomic key to some other, deeper, affinity, and our recognizing its existence marks the end, not the inauguration, of a train of thought."

"Simultaneous discovery is utterly commonplace, and it was only the rarity of scientists, not the inherent improbability of the phenomenon, that made it remarkable in the past. Scientists on the same road may be expected to arrive at the same destination, often not far apart."

"If politics is the art of the possible, research is surely the art of the soluble. Both are immensely practical-minded affairs."

"The human mind treats a new idea the same way the body treats a strange protein; it rejects it."

"Scientific discovery is a private event, and the delight that accompanies it, or the despair of finding it illusory, does not travel. One scientist may get great satisfaction from another’s work and admire it deeply; it may give him great intellectual pleasure; but it gives him no sense of participation in the discovery, it does not carry him away, and his appreciation of it does not depend on his being carried away. If it were otherwise the inspirational origin of scientific discovery would never have been in doubt."

"I could quote evidence of the beginnings of a whispering campaign against the virtues of clarity. A writer on structuralism in the Times Literary Supplement has suggested that thoughts which are confused and tortuous by reason of their profundity are most appropriately expressed in prose that is deliberately unclear. What a preposterously silly idea! I am reminded of an air-raid warden in wartime Oxford who, when bright moonlight seemed to be defeating the spirit of the blackout, exhorted us to wear dark glasses. He, however, was being funny on purpose."

"The purpose of scientific enquiry is not to compile an inventory of factual information, nor to build up a totalitarian world picture of natural Laws in which every event that is not compulsory is forbidden. We should think of it rather as a logically articulated structure of justifiable beliefs about nature."

"Yet the greater part of it, I shall show, is nonsense, tricked out with a variety of metaphysical conceits, and its author can be excused of dishonesty only on the grounds that before deceiving others he has taken great pains to deceive himself."

"In no sense other than an utterly trivial one is reproduction the inverse of chemical disintegration. It is a misunderstanding of genetics to suppose that reproduction is only 'intended' to make facsimiles, for parasexual processes of genetical exchange are to be found in the simplest living things."

"There is much else in the literary idiom of nature-philosophy: nothing-buttery, for example, always part of the minor symptomatology of the bogus."

"The Phenomenon of Man stands square in the tradition of Naturphilosophie, a philosophical indoor pastime of German origin which does not seem even by accident (though there is a great deal of it) to have contributed anything of permanent value to the storehouse of human thought."

"I do not propose to criticize the fatuous argument I have just outlined; here, to expound is to expose."

"How have people come to be taken in by The Phenomenon of Man? We must not underestimate the size of the market for works of this kind, for philosophy-fiction. Just as compulsory primary education created a market catered for by cheap dailies and weeklies, so the spread of secondary and latterly tertiary education has created a large population of people, often with well-developed literary and scholarly tastes, who have been educated far beyond their capacity to undertake analytical thought."

"It is written in an all but totally unintelligible style, and this is construed as prima-facie evidence of profundity."

"French is not a language that lends itself naturally to the opaque and ponderous idiom of nature-philosophy, and Teilhard has according resorted to the use of that tipsy, euphoristic prose-poetry which is one of the more tiresome manifestations of the French spirit."

"It would have been a great disappointment to me if Vibration did not somewhere make itself felt, for all scientistic mystics either vibrate in person or find themselves resonant with cosmic vibrations; but I am happy to say that on page 266 Teilhard will be found to do so."

"In spite of all the obstacles that Teilhard perhaps wisely puts in our way, it is possible to discern a train of thought in The Phenomenon of Man."

"It is not envy or malice, as so many people think, but utter despair that has persuaded many educational reformers to recommend the abolition of the English public schools."

"If a person a) is poorly, b) receives treatment intended to make him better, and c) gets better, no power of reasoning known to medical science can convince him that it may not have been the treatment that restored his health."

"Scientists are entitled to be proud of their accomplishments, and what accomplishments can they call 'theirs' except the things they have done or thought of first? People who criticize scientists for wanting to enjoy the satisfaction of intellectual ownership are confusing possessiveness with pride of possession. Meanness, secretiveness and, sharp practice are as much despised by scientists as by other decent people in the world of ordinary everyday affairs; nor, in my experience, is generosity less common among them, or less highly esteemed."

"It just so happens that during the 1950s, the first great age of molecular biology, the English Schools of Oxford and particularly of Cambridge produced more than a score of graduates of quite outstanding ability —much more brilliant, inventive, articulate and dialectically skilful than most young scientists; right up in the Watson class. But Watson had one towering advantage over all of them: in addition to being extremely clever he had something important to be clever about. This is an advantage which scientists enjoy over most other people engaged in intellectual pursuits, and they enjoy it at all levels of capability. To be a first-rate scientist it is not necessary (and certainly not sufficient) to be extremely clever, anyhow in a pyrotechnic sense. One of the great social revolutions brought about by scientific research has been the democratization of learning. Anyone who combines strong common sense with an ordinary degree of imaginativeness can become a creative scientist, and a happy one besides, in so far as happiness depends upon being able to develop to the limit of one's abilities."

"Watson's childlike vision makes them seem like the creatures of a Wonderland, all at a strange contentious noisy tea-party which made room for him because for people like him, at this particular kind of party, there is always room."

"We cannot point to a single definitive solution of any one of the problems that confront us — political, economic, social or moral, that is, having to do with the conduct of life. We are still beginners, and for that reason may hope to improve. To deride the hope of progress is the ultimate fatuity, the last word in poverty of spirit and meanness of mind. There is no need to be dismayed by the fact that we cannot yet envisage a definitive solution of our problems, a resting-place beyond which we need not try to go."

"Today the world changes so quickly that in growing up we take leave not just of youth but of the world we were young in. I suppose we all realize the degree to which fear and resentment of what is new is really a lament for the memories of our childhood."

"Creosote has a pretty technological smell."

"We shall not read it for its sociological insights, which are non-existent, nor as science fiction, because it has a general air of implausibility; but there is one high poetic fancy in the New Atlantis that stays in the mind after all its fancies and inventions have been forgotten. In the New Atlantis, an island kingdom lying in very distant seas, the only commodity of external trade is — light: Bacon's own special light, the light of understanding."

"We wring our hands over the miscarriages of technology and take its benefactions for granted. We are dismayed by air pollution but not proportionately cheered up by, say, the virtual abolition of poliomyelitis."

"It is the great glory as well as the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute."

"Only human beings guide their behaviour by a knowledge of what happened before they were born and a preconception of what may happen after they are dead; thus only humans find their way by a light that illuminates more than the patch of ground they stand on."

"It can be said with complete confidence that any scientist of any age who wants to make important discoveries must study important problems. Dull or piffling problems yield dull or piffling answers. It is not enough that a problem should be "interesting" - almost any problem is interesting if it is studied in sufficient depth."

"To be creative, scientists need libraries and laboratories and the company of other scientists; certainly a quiet and untroubled life is a help. A scientist's work is in no way deepened or made more cogent by privation, anxiety, distress, or emotional harassment. To be sure, the private lives of scientists may be strangely and even comically mixed up, but not in ways that have any special bearing on the nature and quality of their work. If a scientist were to cut off an ear, no one would interpret such an action as evidence of an unhappy torment of creativity; nor will a scientist be excused any bizarrerie, however extravagant, on the grounds that he is a scientist, however brilliant."

"I believe in "intelligence," and I believe also that there are inherited differences in intellectual ability, but I do not believe that intelligence is a simple scalar endowment that can be quanitified by attaching a single figure to it—an I.Q. or the like."

"I once spoke to a human geneticist who declared that the notion of intelligence was quite meaningless, so I tried calling him unintelligent. He was annoyed, and it did not appease him when I went on to ask how he came to attach such a clear meaning to the notion of lack of intelligence. We never spoke again."

"Observation is the generative act in scientific discovery. For all its aberrations, the evidence of the senses is essentially to be relied upon—provided we observe nature as a child does, without prejudices and preconceptions, but with that clear and candid vision which adults lose and scientists must strive to regain."

"A scientist is no more a collector and classifier of facts than a historian is a man who complies and classifies a chronology of the dates of great battles and major discoveries."

"The attempt to discover and promulgate the truth is nevertheless an obligation upon all scientists, one that must be persevered in no matter what the rebuffs—for otherwise what is the point in being a scientist?"

"No virus is known to do good: it has been well said that a virus is "a piece of bad news wrapped up in protein.""

"I do not believe—indeed, I deem it a comic blunder to believe—that the exercise of reason is sufficient to explain our condition and where necessary to remedy it, but I do believe that the exercise of reason is at all times necessary..."

"When asked to make the formal declaration that I did not intend to overthrow the Constitution of the United States, I was fool enough to reply that I had no such purpose, but that were I to do it by mistake I should be inexpressibly contrite."

"Karl Popper’s conception of the scientific process is that is realistic – it gives a pretty fair picture of what goes on in real life laboratories."

"If for example I had some idea, which as it turned out would be quite wrong, was going off of the tangent, Watson would tell me in no uncertain terms this was nonsense, and vice-versa. If he would have some idea I didn't like, and I would say so, this would shake his thinking about, and draw him back again. And in fact it is one of the requirements for collaborations of this sort, is you must be perfectly candid, one might almost say rude, to the person you're working with. It's useless working with somebody who is either much too junior than yourself or much too senior because then politeness creeps in. And this is the end of all real collaboration in science (giggles)."

"The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry."

"And so to those of you who may be vitalists I would make this prophecy: what everyone believed yesterday, and you believe today, only cranks will believe tomorrow."

"Unlike you and your colleagues I have formed the opinion that there is much substance to Jensen's arguments. In brief I think it likely that more than half the difference between the average I.Q. of American whites and Negroes is due to genetic reasons, and will not be eliminated by any foreseeable change in the environment. Moreover I think the social consequences of this are likely to be rather serious unless steps are taken to recognize the situation."

"I wasn't aware of Chargaff's rules when he said them, but the effect on me was quite electric because I realized immediately that if you had this sort of scheme that John Griffith was proposing, of adenine being paired with thymine, and guanine being paired with cytosine, then you should get Chargaff's rules. I was very excited, but I didn't actually tell Chargaff because it was something I was doing with John Griffith. ... This was very exciting, and we thought "ah ha!" and we realized - I mean what anyone who is familiar with the history of science ought to realize - that when you have one-to-one ratios, it means things go to together. And how on Earth no one pointed out this simple fact in those years, I don't know."

"An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going. But this should not be taken to imply that there are good reasons to believe that it could not have started on the earth by a perfectly reasonable sequence of fairly ordinary chemical reactions. The plain fact is that the time available was too long, the many microenvironments on the earth's surface too diverse, the various chemical possibilities too numerous and our own knowledge and imagination too feeble to allow us to be able to unravel exactly how it might or might not have happened such a long time ago, especially as we have no experimental evidence from that era to check our ideas against."

"Big questions get big answers."

"I argued that it was important not to place too much reliance on any single piece of experimental evidence. It might turn out to be misleading, as the 5.1 Å reflection undoubtedly was. Jim was a little more brash, stating that no good model ever accounted for all the facts, since some data was bound to be misleading if not plain wrong. A theory that did fit all the data would have been "carpentered" to do so and would thus be open to suspicion. (pp. 59-60)"

"Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick."

"Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene."

"What is found in biology is mechanisms, mechanisms built with chemical components and that are often modified by other, later, mechanisms added to the earlier ones. While Occam's razor is a useful tool in the physical sciences, it can be a very dangerous implement in biology. It is thus very rash to use simplicity and elegance as a guide in biological research. While DNA could be claimed to be both simple and elegant, it must be remembered that DNA almost certainly originated fairly close to the origin of life when things were necessarily simple or they would not have got going. Biologists must constantly keep in mind that what they see was not designed, but rather evolved. It might be thought, therefore, that evolutionary arguments would play a large part in guiding biological research, but this is far from the case. It is difficult enough to study what is happening now. To figure out exactly what happened in evolution is even more difficult. Thus evolutionary achievements can be used as hints to suggest possible lines of research, but it is highly dangerous to trust them too much. It is all too easy to make mistaken inferences unless the process involved is already very well understood."

"The job of theorists, especially in biology, is to suggest new experiments. A good theory makes not only predictions, but surprising predictions that then turn out to be true. (If its predictions appear obvious to experimentalists, why would they need a theory?)"

"My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts."

"There is no form of prose more difficult to understand and more tedious to read than the average scientific paper."

"Philosophers have been especially concerned with the problem of consciousness—for example, how to explain the redness of red or the painfulness of pain. This is a very thorny issue. The problem springs from the fact that the redness of red that I perceive so vividly cannot be precisely communicated to another human being, at least in the ordinary course of events. If you cannot describe the properties of a thing unambiguously, you are likely to have some difficulty trying to explain these properties in reductionist terms."

"Our brains have evolved mainly to deal with our body and its interactions with the world it senses to be around us. Is this world real? This is a venerable philosophical issue and I do not wish to be embroiled in the finely honed squabbles to which it has led. I merely state my own working hypothesis: that there is indeed an outside world, and that it is largely independent of our observing it. We can never fully know this outside world, but we can obtain approximate information about some aspects of its properties by using our senses and our brain."

"Before I describe in more detail exactly what is involved in seeing, let me make three general remarks."

"When he discovered the structure of DNA, Francis Crick immediately understood how genetic inheritance works, announcing in the Pub that evening that he understood the secret of life."

"It was not until May of 1986 that I met Francis Crick, at a conference in San Diego. There was a big crowd, full of neuroscientists, but when it was time to sit down for dinner, Crick singled me out, seized me by the shoulders, sat me down next to him, and said, “Tell me stories!” I have no memory of what we ate, or anything else about the dinner, only that I told him stories about many of my patients, and that each one set off bursts of hypotheses, theories, suggestions for investigation in his mind. Writing to Crick a few days later, I said that the experience was “a little like sitting next to an intellectual nuclear reactor…. I never had a feeling of such incandescence.”"

"Conversations with Crick frequently upset Sir Lawrence Bragg, and the sound of his voice was often sufficient to make Bragg move to a safer room. Only infrequently would he come to tea in the Cavendish, since it meant enduring Crick's booming over the tea room."

"I don't know exactly what you guys want to do, but let me tell you why you should do it with fruit flies."

"Any man could, if he were so inclined, be the sculptor of his own brain ( p. xv)."

"Instead of elaborating on accepted principles, let us simply point out that for the last hundred years the natural sciences have abandoned completely the Aristotelian principles of intuition, inspiration, and dogmatism."

"The unique method of reflection indulged in by the Pythagoreans and followers of Plato (and pursued in modern times by Descartes, Fichte, Krause, Hegel, and more recently at least partly by Bergson) involves exploring one’s own mind or soul to discover universal laws and solutions to the great secrets of life."

"This history of civilization proves beyond doubt just how sterile the repeated attempts of metaphysics to guess at nature' s laws have been. Instead, there is every reason to believe that when the human intellect ignores reality and concentrates within, it can no longer explain the simplest inner workings of life' s machinery or of the world around us ( p. 2)."

"The intellect is presented with phenomena marching in review before the sensory organs. It can be truly useful and productive only when limiting itself to the modest tasks of observation, description, and comparison, and of classification that is based on analogies and differences. A knowledge of underlying causes and empirical laws will then come slowly through the use of inductive methods."

"As Claude Bernard has pointed out, researchers cannot transcend the determinism of phenomena; instead, their mission is limited to demonstrating the how, never the why, of observed changes. This is a modest goal in the eyes of philosophy, yet an imposing challenge in actual practice."

"Knowing the conditions under which a phenomenon occurs allows us to reproduce or eliminate it at will, therefore allowing us to control and use it for the benefit of humanity. Foresight and action are the advantages we obtain from a deterministic view of phenomena."

"The severe constraints imposed by determinism may appear to limit philosophy in a rather arbitrary way. However, there is no denying that in the natural sciences — and especially in biology — it is a very effective tool for avoiding the innate tendency to explain the universe as a whole in terms of general laws."

"Now and then philosophers invade the field of biological sciences with these beguiling generalizations, which tend to be unproductive, purely verbal solutions lacking in substance. At best, they may prove useful when viewed simply as working hypotheses."

"There is no doubt that the human mind is fundamentally incapable of solving these formidable problems (the origin of life, nature of matter, origin of movement, and appearance of consciousness). Our brain is an organ of action that is directed toward practical tasks; it does not appear to have been built for discovering the ultimate causes of things, but rather for determining their immediate causes and invariant relationships."

"It is important to note that the most brilliant discoveries have not relied on a formal knowledge of logic. Instead, their discoverers have had an acute inner logic that generates ideas with the same unstudied unconsciousness that allowed Jourdain to create prose."

"In summary, there are no small problems. Problems that appear small are large problems that are not understood (p. 17)."

"Cajal is considered the father of modern neuroscience, as important in his field as Charles Darwin or Louis Pasteur are in theirs (though relatively unknown outside of it)."

"Santiago Ramón y Cajal is recognized as the founder of modern neuroscience, his discoveries representing the fundamental pillars of our current understanding of the nervous system."

"As the decades have passed, one by one all his theories have been corroborated using modern techniques, and the main hypotheses that Cajal postulated have become universally recognized as biological laws: The neuron theory; the law of the dynamic polarization of the neuron and the principle of connectional specificity."

"For most neuroscientists, the roots of our discipline stem from Santiago Ramón y Cajal, the Spanish scientist who, during almost half a century of patient work, showed that the nervous system is made up of independent nerve cells. His studies on the anatomical organization of the brain are still a source of inspiration for many of us. His monumental body of work fully justifies that Ramón y Cajal be singled out as the founder of modern neuroscience."

"Perfect as is the wing of a bird, it never could raise the bird up without resting on air. Facts are the air of a scientist. Without them you never can fly. Without them your "theories" are vain efforts."

"The Sun-Paul must consider only one thing: what is the relation of this or that external reaction of the animal to the phenomena of the external world?"

"Mankind will possess incalculable advantages and extraordinary control over human behavior when the scientific investigator will be able to subject his fellow men to the same external analysis he would employ for any natural object, and when the human mind will contemplate itself not from within but from without."

"Learn the ABC of science before you try to ascend to its summit."

"Learn, compare, collect the facts!"

"I was, I am and will remain the Russian, the son of the Motherland. Her life first of all I will be interested in. I will live with her interests. With her’s dignity I will strengthen mine."

"It makes not a bit of difference that Pavlov was a devout physicalist who felt that a scientific treatment of conscious experience was impossible. In time-honored scientific fashion, good data outlast the orientation of the investigators who collected them."

"Pavlov’s findings were confirmed in the most distressing manner, and on a very large scale, during the two World Wars. As the result of a single catastrophic experience, or of a succession of terrors less appalling but frequently repeated, soldiers develop a number of disabling psycho-physical symptoms. Temporary unconsciousness, extreme agitation, lethargy, functional blindness or paralysis, completely unrealistic responses to the challenge of events, strange reversals of life-long patterns of behaviour—all the symptoms, which Pavlov observed in his dogs, re-appeared among the victims of what in the First World War was called ‘shell shock’, in the Second, ‘battle fatigue’. Every man, like every dog, has his own individual limit of endurance. Most men reach their limit after about thirty days of more or less continuous stress under the conditions of modern combat. The more than averagely susceptible succumb in only fifteen days. The more than averagely tough can resist for forty-five or even fifty days. Strong or weak, in the long run all of them break down. All, that is to say, of those who are initially sane. For, ironically enough, the only people who can hold up indefinitely under the stress of modern war are psychotics. Individual insanity is immune to the consequences of collective insanity."

"One could not be a successful scientist without realizing that, in contrast to the popular conception supported by newspapers and mothers of scientists, a goodly number of scientists are not only narrow-minded and dull, but also just stupid."

"I suspect that in the beginning Maurice hoped that Rosy would calm down. Yet mere inspection suggested that she would not easily bend. By choice she did not emphasize her feminine qualities. Though her features were strong, she was not unattractive and might have been quite stunning had she taken even a mild interest in clothes. This she did not. There was never lipstick to contrast with her straight black hair, while at the age of thirty-one her dresses showed all the imagination of English blue-stocking adolescents. So it was quite easy to imagine her the product of an unsatisfied mother who unduly stressed the desirability of professional careers that could save bright girls from marriages to dull men. But this was not the case. Her dedicated austere life could not be thus explained — she was the daughter of a solidly comfortable, erudite banking family. Clearly Rosy had to go or be put in her place. The former was obviously preferable because, given her belligerent moods, it would be very difficult for Maurice to maintain a dominant position that would allow him to think unhindered about DNA. Not that at times he'd didn't see some reason for her complaints — King's had two combination rooms, one for men, the other for women, certainly a thing of the past. But he was not responsible, and it was no pleasure to bear the cross for the added barb that the women's combination room remained dingily pokey whereas money had been spent to make life agreeable for him and his friends when they had their morning coffee. Unfortunately, Maurice could not see any decent way to give Rosy the boot. To start with, she had been given to think that she had a position for several years. Also there was no denying that she had a good brain. If she could keep her emotions under control, there was a good chance she could really help him. But merely wishing for relations to improve was taking something of a gamble, for Cal Tech's fabulous chemist Linus Pauling was not subject to the confines of British fair play. Sooner or later Linus, who had just turned fifty, was bound to try for the most important of all scientific prizes. There was no doubt he was interested. … The thought could not be avoided that the best home for a feminist was in another person's lab."

"Watson: But legalities aside, I think we must reevaluate our basic assumptions about the meaning of life. Perhaps, as my former colleague Francis Crick suggested, no one should be thought alive until about three days after birth."

"Prism: But how would society react to such a proposal?"

"Watson: Our society just hasn't faced up to this problem. In a primitive society, if you saw that a baby was deformed, you would abandon it on a hillside. Today this isn't permissible, and with our medicine getting better and better in the sense of being able to keep sick people alive longer, we are going to produce more people living wretched lives. I don't know how you get a society to change on such a basic issue; infanticide isn't regarded lightly by anyone. Fortunately, now through such techniques as amniocentesis, parents can often learn in advance whether their child will be normal and healthy or hopelessly deformed. They then can choose either to have the child or opt for a therapeutic abortion. But the cruel fact remains that because of the present limits of such detection methods, most birth defects are not discovered until birth. If the child were not declared alive until three days after birth, then all parents could be allowed the choice that only a few are given under the present system. The doctor could allow the child to die if the parents so chose and save a lot of misery and suffering. I believe this view is the only rational, compassionate attitude to have."

"The brain is the last and grandest biological frontier, the most complex thing we have yet discovered in our universe. It contains hundreds of billions of cells interlinked through trillions of connections. The brain boggles the mind."

"There is only one science, physics: everything else is social work."

"When anti-DNA doomsday scenarios failed to materialize, even the modestly restrictive governmental regulations began to wither away. In retrospect, recombinant-DNA may rank as the safest revolutionary technology ever developed. To my knowledge, not one fatality, much less illness, has been caused by a genetically manipulated organism. The moral I draw from this painful episode is this: Never postpone experiments that have clearly defined future benefits for fear of dangers that can't be quantified. Though it may sound at first uncaring, we can react rationally only to real (as opposed to hypothetical) risks."

"Moving forward will not be for the faint of heart. But if the next century witnesses failure, let it be because our science is not yet up to the job, not because we don't have the courage to make less random the sometimes most unfair courses of human evolution."

"To have success in science, you need some luck. But to succeed in science, you need a lot more than luck. And it's not enough to be smart — lots of people are very bright and get nowhere in life. In my view, you have to combine intelligence with a willingness not to follow conventions when they block your path forward."

"To succeed in science, you have to avoid dumb people (here I was still following Luria's example). Now that might sound inexcusably flip, but the fact is that you must always turn to people who are brighter than yourself."

"To make a huge success, a scientist must be prepared to get into deep trouble. Sometime or another, someone will tell you that you are not ready to do something. … If you are going to make a big jump in science, you will very likely be unqualified to succeed by definition. The truth, however, won't save you from criticism. Your very willingness to take on a very big goal will offend some people who will think that you are too big for your britches and crazy to boot."

"Be sure you have someone up your sleeve who will save you when you find yourself in deep s—."

"Never do anything that bores you. My experience in science is that someone is always telling to do something that leaves you flat. Bad idea. I'm not good enough to do something I dislike. In fact, I find it hard enough to do something that I like. … Constantly exposing your ideas to informed criticism is very important, and I would venture to say that one reason both of our chief competitors failed to reach the Double Helix before us was that each was effectively very isolated."

"Whenever you interview fat people, you feel bad, because you know you're not going to hire them."

"No one may have the guts to say this, but if we could make better human beings by knowing how to add genes, why shouldn't we?"

"If we don't play God, who will?"

"I just can’t sit while people are saying nonsense in a meeting without saying it’s nonsense."

"People say it would be terrible if we made all girls pretty. I think it would be great."

"Never be the brightest person in the room. … We're all imperfect."

"Science Ph.D. students have effectively become serfs. And who would become a serf when you can work for Goldman Sachs and get paid $300,000 a year to become a serf? Why drive a Chevy when you can drive a BMW — and now you're condemned to driving a car from Malaysia or something. Life should be fun."

"New ideas require new facts. You explain things by way of ideas. Why do we have a government that is run by rich trash? Because they've used their money to buy the presidency. Bush is a tool for the people who don't want an inheritance tax."

"For all my life, America was the place to be. And we somehow continue to be the place where there are real opportunities to change the world for the better. I'm basically a libertarian. I don't want to restrict anyone from doing anything unless it's going to harm me. I don't want to pass a law stopping someone from smoking. It's just too dangerous. You lose the concept of a free society. Since we are genetically so diverse and our brains are so different, we're going to have different aspirations. The things that will satisfy me won't satisfy you. On the other hand, if global warming is in any way preventable and it's likely to come, not doing something would be irresponsible to the future of our society."

"Should you be allowed to make an anti-Semitic remark? Yes, because some anti-Semitism is justified. Just like some anti-Irish feeling is justified. If you can't be criticized, that's very dangerous. The whole Larry Summers thing, to say that men are a bit strange and their strangest quality is their ability to understand mathematics -- you're not supposed to even think it."

"I turned against the left wing because they don't like genetics, because genetics implies that sometimes in life we fail because we have bad genes. They want all failure in life to be due to the evil system."

"If you could make people with ten-point-higher IQs, we'd probably have fewer wars."

"I've seen no evidence of a god, so I'm not going to think about one. Being raised nonreligious made you free. You could look at the evidence. Whether being nonreligious or a Democrat was more important, I can't tell you."

"Do things as soon as you can. If a decision needs to be made, make it. It gives you more time to change your mind."

"Science is no stranger to controversy. The pursuit of discovery, of knowledge, is often uncomfortable and disconcerting. I have never been one to shy away from stating what I believe to be the truth, however difficult it might prove to be. This has, at times, got me in hot water. Rarely more so than right now, where I find myself at the centre of a storm of criticism. I can understand much of this reaction. For if I said what I was quoted as saying, then I can only admit that I am bewildered by it. To those who have drawn the inference from my words that Africa, as a continent, is somehow genetically inferior, I can only apologise unreservedly. That is not what I meant. More importantly from my point of view, there is no scientific basis for such a belief. I have always fiercely defended the position that we should base our view of the world on the state of our knowledge, on fact, and not on what we would like it to be. This is why genetics is so important. For it will lead us to answers to many of the big and difficult questions that have troubled people for hundreds, if not thousands, of years. But those answers may not be easy, for, as I know all too well, genetics can be cruel. My own son may be one of its victims. Warm and perceptive at the age of 37, Rufus cannot lead an independent life because of schizophrenia, lacking the ability to engage in day-to-day activities."

"Since 1978, when a pail of water was dumped over my Harvard friend E. O. Wilson for saying that genes influence human behaviour, the assault against human behavioural genetics by wishful thinking has remained vigorous. But irrationality must soon recede. It will soon be possible to read individual genetic messages at costs which will not bankrupt our health systems. In so doing, I hope we see whether changes in DNA sequence, not environmental influences, result in behaviour differences. Finally, we should be able to establish the relative importance of nature as opposed to nurture."

"The thought that some people are innately wicked disturbs me. But science is not here to make us feel good. It is to answer questions in the service of knowledge and greater understanding. In finding out the extent to which genes influence moral behaviour, we shall also be able to understand how genes influence intellectual capacities."

"Right now, at my institute in the US we are working on gene-caused failures in brain development that frequently lead to autism and schizophrenia. We may also find that differences in these respective brain development genes also lead to differences in our abilities to carry out different mental tasks. In some cases, how these genes function may help us to understand variations in IQ, or why some people excel at poetry but are terrible at mathematics. All too often people with high mathematical abilities have autistic traits. The same gene that gives some people such great mathematical abilities may also lead to autistic behaviour. This is why, in studying autism and schizophrenia, we believe that we shall come very close to a better understanding of intelligence and, therefore, of the differences in intelligence."

"We do not yet adequately understand the way in which the different environments in the world have selected over time the genes which determine our capacity to do different things. The overwhelming desire of society today is to assume that equal powers of reason are a universal heritage of humanity. It may well be. But simply wanting this to be the case is not enough. This is not science. To question this is not to give in to racism. This is not a discussion about superiority or inferiority, it is about seeking to understand differences, about why some of us are great musicians and others great engineers. It is very likely that at least some 10 to 15 years will pass before we get an adequate understanding for the relative importance of nature versus nurture in the achievement of important human objectives. Until then, we as scientists, wherever we wish to place ourselves in this great debate, should take care in claiming what are unarguable truths without the support of evidence."

"No one really wants to admit I exist."

"Not at all. I would like for them to have changed, that there be new knowledge that says that your nurture is much more important than nature. But I haven’t seen any knowledge. And there’s a difference on the average between blacks and whites on I.Q. tests. I would say the difference is, it’s genetic."

"Crick, however, was right. Our discovery put an end to a debate as old as the human species: Does life have some magical, mystical essence, or is it, like any chemical reaction carried out in a science class, the product of normal physical and chemical processes? Is there something divine at the heart of a cell that brings it to life? The double helix answer that question with a definitive No."

"That is why the double helix was so important. It brought the Enlightenment revolution in materialistic thinking into the cell. The intellectual journey that had begun with Copernicus displacing humans from the center of the universe and continued with Darwin’s insistence that humans are merely modified monkeys had finally focused in on the very essence of life. And there was nothing special about it. The double helix is an elegant structure, but its message is downright prosaic: life is simply a matter of chemistry."

"The discovery of the double helix sounded the death knell for vitalism. Serious scientists, even those religiously inclined, realized that a complete understanding of life would not require the revelation of new laws of nature. Life was just a matter of physics and chemistry, albeit exquisitely organized physics and chemistry. The immediate task ahead would be to figure out how the DNA-encoded script of life went about its work."

"The problem was insoluble: you cannot, we thought, have DNA without proteins, and you cannot have proteins without DNA. RNA, however, being a DNA equivalent (it can store and replicate genetic information) as well as a protein equivalent (it can catalyze critical chemical reactions) offers an answer. In fact, in the “RNA world” the chicken-and-egg problem simply disappears. RNA is both the chicken and the egg. RNA is an evolutionary heirloom. Once natural selection has solved a problem, it tends to stick with that solution, in effect following the maxim “if it ain’t broke, don’t fix it.” In other words, in the absence of selective pressure to change, cellular systems do not innovate and so bear many imprints of the evolutionary past. A process may be carried out in a certain way simply because it first evolved that way, not because that is absolutely the best and most efficient way."

"The opposition to GM foods is largely a sociopolitical movement whose arguments, though couched in the language of science, are typically unscientific. Indeed, some of the anti-GM pseudoscience propagated by the media—whether in the interests of sensationalism or out of misguided but well-intentioned concern—would be actually amusing were it not evident that such gibberish is in fact an effective weapon in the propaganda war."

"Sure enough, the notion of decoding their personal DNA appealed to more than a few well-off individuals, even if it amounted to the scientific equivalent of purchasing a vanity license plate."

"Khan analyzed the data and was relieved to find that his son’s DNA was “pretty boring.” In the brave new world of personal genomics, “boring” is the new “great.”"

"Our low gene count by no means invalidates a reductionist approach to biological systems, nor does it justify any logical inference that we are not determined by our genes. A fertilized egg containing a chimp genome still inevitably produces a chimp, while a fertilized egg containing a human genome produces a human. No amount of exposure to classical music or violence on TV could make it otherwise. Yes, we have a long way to go in developing our understanding of just how the information in those two remarkably similar genomes is applied to the task of producing two apparently very different organisms, but the fact remains that the greatest part of what each individual organism will be is programmed ineluctably into its every cell, in the genome."

"This remarkable feat merely reaffirms what most of us in molecular biology have long known to be the truth: the essence of life is complicated chemistry and nothing more."

"The conclusion that we nearly all carry components of Neanderthal DNA in our genomes, although perhaps a blow to our collective ego, does not appear quite so surprising upon reflection. Indeed, the overall lesson of molecular studies of human evolution is just how astonishingly close we are genetically to the rest of the natural world. In fact, molecular data have often challenged (and overthrown) long-held assumptions about human origins."

"Given what a powerful determinant, mostly for ill, skin color has been in human history and individual experience, it is surprising how little we know about its underlying genetics. This deficit, however, may have had less to do with the limitations of our science and more with the intrusion of politics into science; in an academic world terrorized by political correctness, even to study the molecular basis of such a characteristic has been something of a taboo."

"The law has always had difficulty assimilating the implications, if not the very idea, of scientific evidence. Even the most intelligent lawyers, judges, and juries have customarily found it difficult to understand at first."

"My youthful reasoning on the subject, however absurdly misinformed, nevertheless taught me a very valuable lesson: the danger of assuming that genes are responsible for differences we see among individuals or groups. We can err mightily unless we can be confident that environmental factors have not played the more decisive role. This tendency to prefer explanations grounded in “nurture” over ones rooted in “nature” has served a useful social purpose in redressing generations of bigotry. Unfortunately, we have now cultivated too much of a good thing. The current epidemic of political correctness has delivered us to a moment when even the possibility of a genetic basis for difference is a hot potato: there is a fundamentally dishonest resistance to admitting the role our genes almost surely play in setting one individual apart from another."

"And so having signed on to the liberal end of the political spectrum, and finding themselves in a climate intolerant of truths that don’t conform to ideology, most scientists carefully steer clear of research that might uncover such truths. The fact that they duly hew to the prevailing line of liberal orthodoxy—which seeks to honor and entitle difference while shunning any consideration of its biochemical basis—is, I think, bad for science, for a democratic society, and ultimately for human welfare."

"Knowledge, even that which may unsettle us, it surely to be preferred to ignorance, however blissful in the short term the latter may be. All too often, however, political anxiousness favors ignorance and its apparent safety: we had better not learn about the genetics of skin color, goes the unspoken fear, lest such information be marshaled somehow by hatemongers opposed to mixing among the races."

"The tendency is to focus on the worst-case scenario and to shy away from potentially controversial science; it is time, I think, we looked instead at the benefits."

"Ideology—of any kind—and science are at best inappropriate bedfellows. Science may indeed uncover unpleasant truths, but the critical thing is that they are truths. Any effort, whether wicked or well-meaning, to conceal truth or impede its disclosure is destructive. Too often in our free society, scientists willing to take on questions with political ramifications have been made to pay an unjust price."

"Murray and Herrnstein’s assertion, however, was that the discrepancy was so great that environment likely couldn’t explain it all. Similarly, environmental factors alone may not account for why, globally, Asians have on average higher IQs than other racial groups. The idea of measurable variations in average intelligence among ethnic groups is not one, I admit, I want to live with. But though The Bell Curve’s claims remain questionable, we should not allow political anxieties to keep us from looking into them further."

"The finding that there is a substantial genetic component to our behavior should not surprise us; indeed, it would be far more surprising if this were not the case. We are products of evolution: among our ancestors, natural selection indubitably exerted a strong influence over all traits that have figured in our survival."

"The future promises a detailed genetic dissection of personality, and it is hard to imagine that what we discover will not tip the scales of the nature/nurture debate more and more in the direction of nature—a frightening thought for some, but only if we persist in being held hostage by a static, ultimately meaningless dichotomy. To find that any trait, even one with formidable political implications, has a mainly genetic basis is not to find something set immutably in stone. It is merely to understand the nature upon which nurture is ever acting, and those things we, as a society and as individuals, need to do if we are better to assist the process. Let us not allow transient political considerations to set the scientific agenda. Yes, we may uncover truths that make us uneasy in the light of our present circumstances, but it is those circumstances, not nature’s truth, to which policy makers ought to address themselves."

"Life, we now know, is nothing but a vast array of coordinated chemical reactions. The “secret” to that coordination is the breathtakingly complex set of instructions inscribed—again, chemically—in our DNA."

"If, therefore, we are serious about improving education, we cannot in good conscience ultimately limit ourselves to seeking remedies in nurture. My suspicion, however, is that education policies are too often set by politicians to whom the glib slogan “Leave no child behind” appeals precisely because it is so completely unobjectionable. But children will get left behind if we continue to insist that each one has the same potential for learning."

"The issue, rather, is this: Are we prepared to embrace the undeniably vast potential of genetics to improve the human condition, individually and collectively? Most immediate, would we want the guidance of genetic information to design learning best suited to our children’s individual needs?"

"The reality is that the idea of improving on the genes that nature has given us alarms people. When discussing our genes, we seem ready to commit what philosophers call the naturalistic fallacy, assuming that the way nature intended it is best. By centrally heating our homes and taking antibiotics when we have an infection, we carefully steer clear of the fallacy in our daily lives, but mentions of genetic improvement have us rushing to run the “nature knows best” flag up the mast. For this reason, I think that the acceptance of genetic enhancement will most likely come about through efforts to prevent disease."

"I find such a moralistic response to be profoundly immoral."

"But even if we allow hypothetically that gene enhancement could—like any powerful technology—be applied to nefarious social ends, that only strengthens the case for our developing it. Considering the near impossibility of repressing technological progress, and the fact that much of what is now prohibited is well on its way to becoming practicable, do we dare restrain our own research community and risk allowing some culture that does not share our values to gain the upper hand? From the time the first of our ancestors fashioned a stick into a spear, the outcomes of conflicts throughout history have been dictated by technology."

"And so if there is a paramount ethical issue attending the vast new genetic knowledge created by the Human Genome Project, in my view it is the slow pace at which what we now know is being deployed to diminish human suffering. Leaving aside the uncertainties of gene therapy, I find the lag in embracing even the most unambiguous benefits to be utterly unconscionable. That in our medically advanced society almost no women are screened for the fragile X mutation two decades after its discovery can attest only to ignorance or intransigence."

"I do not dispute the right of individuals to look to religion for a private moral compass, but I do object to the assumption of too many religious people that atheists live in a moral vacuum. Those of us who feel no need for a moral code written down in an ancient tome have, in my opinion, recourse to an innate moral intuition long ago shaped by natural selection promoting social cohesion in groups of our ancestors."

"With its direct contradiction of religious accounts of creation, evolution represents science’s most direct incursion into the religious domain and accordingly provokes the acute defensiveness that characterizes creationism."

"There is in the first place its scientific interest. The discovery of the structure by Crick and Watson, with all its biological implications, has been one of the major scientific events of this century. The number of researches which it has inspired is amazing; it has caused an explosion in biochemistry which has transformed the science. I have been amongst those who have pressed the author to write his recollections while they are still fresh in his mind, knowing how important they would be as a contribution to the history of science. The result has exceeded expectation. The latter chapters, in which the birth of the new idea is described so vividly, are drama of the highest order; the tension mounts and mounts towards the final climax. I do not know of any other instance where one is able to share so intimately in the researcher's struggles and doubts and final triumph. Then again, the story is a poignant example of a dilemma which may confront an investigator. He knows that a colleague has been working for years on a problem and has accumulated a mass of hard-won evidence, which has not yet been published because it is anticipated that success is just around the comer. He has seen this evidence and has good reason to believe that a method of attack which he can envisage, perhaps merely a new point of view, will lead straight to the solution. An offer of collaboration at such a stage might well be regarded as a trespass. Should he go ahead on his own It is not easy to be sure whether the crucial new idea is really one's own or has been unconsciously assimilated in talks with others. The realization of this difficulty has led to the establishment of a some what vague code amongst scientists which recognizes a claim in a line of research staked out by a colleague up to a certain point. When competition comes from more than one quarter, there is no need to hold back. This dilemma comes out clearly in the DNA story. It is a source of deep satisfaction to all intimately concerned that, in the award of the Nobel Prize in 1962, due recognition was given to the long, patient investigation by Wilkins at King's College (London) as well as to the brilliant and rapid final solution by Crick and Watson at Cambridge. Finally, there is the human interest of the story the impression made by Europe and by England in particular upon a young man from the States. He writes with a Pepys like frankness. Those who figure in the book must read it in a very forgiving spirit. One must remember that his book is not a history, but an autobiographical contribution to the history which will some day be written. As the author himself says, the book is a record of impressions rather than historical facts. The issues were often more complex, and the motives of those who had to deal with them were less tortuous, than he realized at the time. On the other hand, one must admit that his intuitive understanding of human frailty often strikes home."

"He says that he is “inherently gloomy about the prospect of Africa” because “all our social policies are based on the fact that their intelligence is the same as ours – whereas all the testing says not really”, and I know that this “hot potato” is going to be difficult to address. His hope is that everyone is equal, but he counters that “people who have to deal with black employees find this not true”. He says that you should not discriminate on the basis of colour, because “there are many people of colour who are very talented, but don’t promote them when they haven’t succeeded at the lower level”. He writes that “there is no firm reason to anticipate that the intellectual capacities of peoples geographically separated in their evolution should prove to have evolved identically. Our wanting to reserve equal powers of reason as some universal heritage of humanity will not be enough to make it so”."

"Consistently rated as one of the greatest books written about science in the past century, it has been hailed as a work that combines the plot line of a racy novel with deep insights about the nature of modern research. But James Watson, author of The Double Helix, has revealed that his masterpiece came close to being suppressed. In an exclusive interview with the Observer, he admitted last week that his account of the discovery of the structure of DNA, when shown to friends and colleagues in the late 60s, triggered such hostility and outrage it seemed fated never to appear in print. … Many publishers were frightened off by threats of legal action from the manuscript's critics. Watson's depictions of several scientists were deeply unflattering and the book's secondary plot, which focuses on Watson's pursuit of young women – or "popsies" as he called them – around Cambridge, was considered irrelevant and patronising. Harvard University Press, having accepted Watson's manuscript for publication, came under pressure from the university's senior administrators and dropped the book. It took the intervention of Lady Alice Bragg, the wife of Watson's former boss, Sir [William] Lawrence Bragg, to save The Double Helix, Watson has revealed."

"The Double Helix opens with the words: "I have never seen Francis Crick in a modest mood." I have never seen James D Watson in a modest mood, either. He is not an innately modest person. In his later years he would consent to press briefings – usually on important anniversaries – and then, with long pauses and enigmatic mumbles, say almost nothing. This was not because he was self-effacing or disliked controversy. He would say almost nothing, one sensed, because he couldn't be bothered with stupid questions from stupid people. He has made it clear more than once that this is his default attitude."

"For a large number of problems there will be some animal of choice or a few such animals on which it can be most conveniently studied."

"I can now rejoice even in the falsification of a cherished theory, because even this is a scientific success."

"In order that a "self" may exist there must be some continuity of mental experiences and, particularly, continuity bridging gaps of unconsciousness. For example, the continuity of our "self" is resumed after sleep, anaesthesia, and the temporary amnesias of concussion and convulsions."

"I believe that there is a fundamental mystery in my existence, transcending any biological account of the development of my body (including my brain) with its genetic inheritance and its evolutionary origin. … I cannot believe that this wonderful gift of a conscious existence has no further future, no possibility of another existence under some other unimaginable conditions."

"Our coming-to-be is as mysterious as our ceasing-to-be at death. Can we therefore not derive hope because our ignorance about our origin matches our ignorance about our destiny? Cannot life be lived as a challenging and wonderful adventure that has meaning yet to be discovered? (95)"

"I have read a great deal now on the neurological side and much on the anthropological side and on the philosophical side and we have had all these discussions and all the time I have the feeling that something may break. I mean that some little light at the end of the tunnel may be sensed or some flash of insight may come. I of course know very well that there is no guarantee it will come, but I have already got myself into this state of expectancy that something will come to my imagination which has some germ of truth about it in this most difficult field."

"I maintain that the human mystery is incredibly demeaned by scientific reductionism, with its claim in promissory materialism to account eventually for all of the spiritual world in terms of patterns of neuronal activity. This belief must be classed as a superstition … we have to recognize that we are spiritual beings with souls existing in a spiritual world as well as material beings with bodies and brains existing in a material world."

"The more we discover scientifically about the brain the more clearly do we distinguish between the brain events and the mental phenomena and the more wonderful do the mental phenomena become. Promissory materialism is simply a superstition held by dogmatic materialists. It has all the features of a Messianic prophecy, with the promise of a future freed of all problems—a kind of Nirvana for our unfortunate successors."

"The materialist critics argue that insuperable difficulties are encountered by the hypothesis that immaterial mental events can act in any way on material structures such as neurons. Such a presumed action is alleged to be incompatible with the conservation laws of physics, in particular of the first law of thermodynamics. This objection would certainly be sustained by nineteenth century physicists, and by neuroscientists and philosophers who are still ideologically in the physics of the nineteenth century, not recognizing the revolution wrought by quantum physicists in the twentieth century."

"Induction was shown to be untenable as a scientific method by Popper in The Logic of Scientific Discovery (1959). Instead, advances in scientific understanding come ideally from hypothetico-deductivism: firstly, development of a hypothesis in relation to a problem situation, and secondly, its testing in relation to all relevant knowledge and furthermore by its great explanatory power."

"The concept of substance leads to a materialist aspect of the mind. I speak instead of the spiritual existence of the self without mentioning any 'substance' properties. The great problem is 'how the self controls its brain'. This is dualistic, but not in terms of two substances. Instead it relates to the two worlds of Popper."

"The hypothesis has been proposed that all mental events and experiences, in fact the whole of the outer and inner sensory experiences, are a composite of elemental or unitary mental experiences at all levels of intensity. Each of these mental units is reciprocally linked in some unitary manner to a dendron … Appropriately we name these proposed mental units 'psychons.' Psychons are not perceptual paths to experiences. They are the experiences in all their diversity and uniqueness. There could be millions of psychons each linked uniquely to the millions of dendrons. It is hypothesized that it is the very nature of psychons to link together in providing a unified experience."

"Too much equipment can be, however, something that hampers scientific development. I had the feeling that if there is no equipment present, everybody is forced to simplify his ideas in such a way that the experiments become simple. If there is too much equipment available, he can attack any experiment immediately since all the difficulties will be overcome by putting more money in the equipment. In the long run, some of the equipment becomes so complicated that it is difficult to see how all the parts interact."

"If we want to make a discovery, we have to take a risk, since everything new was discovered by accident or by the fact that somebody took a chance and went ahead when there wasn't 100 percent safety for the solution."

"It is not the things that we have, but how we use them that is important."

"Ionizing radiation has always been with us and will be for all foreseeable time. Our genetic system is probably well adjusted by natural selection to normal background radiation. Added radiation will increase the frequency of mutations; most of these will be harmful. Exposure to radiation in large amounts will increase malignant disease; small amounts may possibly do the same. In view of these potentially harmful effects every reasonable effort should be made to reduce the levels of ionizing radiation to which man is exposed to to the lowest levels that can reasonably be attained."

"The curiosity remains... to grasp more clearly how the same matter, which in physics and chemistry displays orderly and reproducible and relatively simple properties, arranges itself in the most astounding fashions as soon as it is drawn into the orbit of the living organism. The closer one looks at these performances of matter in living organisms the more impressive the show becomes. The meanest living cell becomes a magic puzzle box full of elaborate and changing molecules, and far outstrips all chemical laboratories of man in the skill of organic synthesis performed with ease, expedition, and good judgment of balance."

"Any living cell carries with it the experiences of a billion years of experimentation by its ancestors. You cannot expect to explain so wise an old bird in a few simple words."

"If you're too sloppy, then you never get reproducible results, and then you never can draw any conclusions; but if you are just a little sloppy, then when you see something startling, (...) you nail it down (...). So I called it the "Principle of Limited Sloppiness"."

"The progress of science is tremendously disorderly, and the motivations that lead to this progress are tremendously varied, and the reasons why scientists go into science, the personal motivations, are tremendously varied. I have said … that science is a haven for freaks, that people go into science because they are misfits, and that it is a sheltered place where they can spin their own yarn and have recognition, be tolerated and happy, and have approval for it."

"The particular thing about science is to combine that [the dreams of obtaining power] with a retreat from the world. Other people want to obtain power by going out into the world, but the scientist really wants to obtain power by retreating from the world."

"The scientist addresses an infinitesimal audience of fellow composers. His message is not devoid of universality but it's universality is disembodied and anonymous. While the artist's communication is linked forever with it's original form, that of the scientist is modified, amplified, fused with the ideas and results of others, and melts into the stream of knowledge and ideas which forms our culture. The scientist has in common with the artist only this: that he can find no better retreat from the world than his work and also no stronger link with his world than his work."

"The problem was well expressed by Max Delbrück, one of Schrödinger's contemporaries, who expressed it in this way... so to encapsulate what Delbrück was saying is that, at the level of atoms it's just known physics, but at the level of the living cell, it's some sort of magic."

"How scientists go about their job: and it's a process, it's a question of asking questions, respecting observation, respecting experiment, having tentative explanations and then testing them.... There is a problem sometimes with how we teach science at schools. Because we sometimes teach it as if it has been chiseled in stone."

"Even at the level of the cell, phenomena such as general cellular homeostasis and the maintenance of cell integrity, the generation of spatial and temporal order, inter- and intracellular signalling, cell 'memory' and reproduction are not fully understood. ...This is also true for the levels of organization seen in tissues, organs and organisms, which feature more complex phenomena such as and operation of the immune and s."

"We need to focus more on how information is managed in living systems and how this brings about higher level biological phenomena... more investigation into how living systems gather, process, store and use information, as was emphasized at the birth of ."

"DNA can act as a digital information storage device that can be precisely copied. Similarly, the mechanism of the lac operon... can be described in terms of molecular interactions between DNA, protein and s. But these interactions make sense only when they are translated into a negative loop..."

"We need to describe the molecular interactions and biochemical transformations that take place in living organisms, and then translate these descriptions into the logic circuits that reveal how information is managed. This analysis should not be confined to the flow of information from to , but should also be applied to all functions operating in cells and organisms, including chemical interactions and transformations as well as physical phenomena, such as electrical signalling and mechanical processes."

"Ever since Sir Isaac Newton's times, scientists have worked in the same sort of way:"

"This notion of information being at the heart of life... is not restricted to me. I'm in good company. Sir Paul Nurse, former president of the Royal Society, in his visionary essay in Nature, "Life, Logic and Information", extols the virtues of thinking in an information, web-based way about life, and how, instead of worrying too much about what is going on at the molecular level, we should think of life as being a collection of logic modules... with information flowing between them, and control systems... a sort of engineering approach."

"The same individual geese on which we conducted these experiments, first aroused my interest in the process of domestication. They were F1 hybrids of wild Greylags and domestic geese and they showed surprising deviations from the normal social and sexual behaviour of the wild birds. I realised that an overpowering increase in the drives of feeding as well as of copulation and a waning of more differentiated social instincts is characteristic of very many domestic animals. I was frightened – as I still am – by the thought that analogous genetical processes of deterioration may be at work with civilized humanity. Moved by this fear, I did a very ill-advised thing soon after the Germans had invaded Austria: I wrote about the dangers of domestication and, in order to be understood, I couched my writing in the worst of nazi-terminology. I do not want to extenuate this action. I did, indeed, believe that some good might come of the new rulers. The precedent narrow-minded catholic regime in Austria induced better and more intelligent men than I was to cherish this naive hope. Practically all my friends and teachers did so, including my own father who certainly was a kindly and humane man. None of us as much as suspected that the word "selection", when used by these rulers, meant murder. I regret those writings not so much for the undeniable discredit they reflect on my person as for their effect of hampering the future recognition of the dangers of domestication."

"It is a good morning exercise for a research scientist to discard a pet hypothesis every day before breakfast. It keeps him young."

"All too willingly man sees himself as the centre of the universe, as something not belonging to the rest of nature but standing apart as a different and higher being. Many people cling to this error and remain deaf to the wisest command ever given by a sage, the famous "Know thyself" inscribed in the temple of Delphi."

"The scientist who considers himself absolutely "objective" and believes that he can free himself from the compulsion of the "merely" subjective should try — only in imagination of course — to kill in succession a lettuce, a fly, a frog, a guineapig, a cat, a dog, and finally a chimpanzee. He will then be aware how increasingly difficult murder becomes as the victim's level of organisation rises. The degree of inhibition against killing each one of these beings is a very precise measure for the considerably different values that we cannot help attributing to lower and higher forms of life. To any man who finds it equally easy to chop up a live dog and a live lettuce I would recommend suicide at his earliest convenience!"

"We are the highest achievement reached so far by the great constructors of evolution. We are their "latest" but certainly not their last word. The scientist must not regard anything as absolute, not even the laws of pure reason. He must remain aware of the great fact, discovered by Heraclitus, that nothing whatever really remains the same even for one moment, but that everything is perpetually changing. To regard man, the most ephemeral and rapidly evolving of all species, as the final and unsurpassable achievement of creation, especially at his present-day particularly dangerous and disagreeable stage of development, is certainly the most arrogant and dangerous of all untenable doctrines. If I thought of man as the final image of God, I should not know what to think of God. But when I consider that our ancestors, at a time fairly recent in relation to the earth's history, were perfectly ordinary apes, closely related to chimpanzees, I see a glimmer of hope. It does not require very great optimism to assume that from us human beings something better and higher may evolve. Far from seeing in man the irrevocable and unsurpassable image of God, I assert – more modestly and, I believe, in greater awe of the Creation and its infinite possibilities – that the long-sought missing link between animals and the really humane being is ourselves!"

"Nobody can seriously believe that free will means that it is left entirely to the will of the individual, as to an irresponsible tyrant, to do or not do whatever he pleases. Our freest will underlies strict moral laws, and one of the reasons for our longing for freedom is to prevent our obeying other laws than these. It is significant that the anguished feeling of not being free is never evoked by the realisation that our behaviour is just as firmly bound to moral laws as physiological processes are to physical ones. We are all agreed that the greatest and most precious freedom of man is identical with the moral laws within him. Increasing knowledge of the natural causes of his own behaviour can certainly increase a man's faculties and enable him to put his free will into action, but it can never diminish his will. If, in the impossible case of an utopian complete and ultimate success of causal analysis, man should ever achieve complete insight into the causality of earthly phenomena, including the workings of his own organism, he would not cease to have a will but it would be in perfect harmony with the incontrovertible lawfulness of the universe, the Weltvernunft of the Logos. This idea is foreign only to our present-day western thought; it was quite familiar to ancient Indian philosophy and to the mystics of the middle ages."

"I now come to the third great obstacle to human self-knowledge, to the belief — deeply rooted in our western culture — that what can be explained in terms of natural science has no values. This belief springs from an exaggeration of Kant's values-philosophy, the consequence of the idealistic dichotomy of the world into the external world of things and the internal laws of human reason."

"The attitude of the true scientist towards the real limits of human understanding was unforgettably impressed on me in early youth by the obviously unpremeditated words of a great biologist; Alfred Kuhn finished a lecture to the Austrian Academy of Science with Goethe's words, "It is the greatest joy of the man of thought to have explored the explorable and then calmly to revere the inexplorable." After the last word he hesitated, raised his hand in repudiation and cried, above the applause, "No, not calmly, gentlemen; not calmly!""

"Nothing can better express the feelings of the scientist towards the great unity of the laws of nature than in Immanuel Kant's words: "Two things fill the mind with ever new and increasing awe: the stars above me and the moral law within me."… Would he, who did not yet know of the evolution of the world of organisms, be shocked that we consider the moral law within us not as something given, a priori, but as something which has arisen by natural evolution, just like the laws of the heavens?"

"Let us imagine that an absolutely unbiased investigator on another planet, perhaps on Mars, is examining human behavior on earth, with the aid of a telescope whose magnification is too small to enable him to discern individuals and follow their separate behavior, but large enough for him to observe occurrences such as migrations of peoples, wars, and similar great historical events. He would never gain the impression that human behavior was dictated by intelligence, still less by responsible morality."

"All the advantages that man has gained from his ever-deepening understanding of the natural world that surrounds him, his technological, chemical and medical progress, all of which should seem to alleviate human suffering... tends instead to favor humanity's destruction."

"The competition between human beings destroys with cold and diabolic brutality.... Under the pressure of this competitive fury we have not only forgotten what is useful to humanity as a whole, but even that which is good and advantageous to the individual.... One asks, which is more damaging to modern humanity: the thirst for money or consuming haste... in either case, fear plays a very important role: the fear of being overtaken by one's competitors, the fear of becoming poor, the fear of making wrong decisions or the fear of not being up to snuff."

"Mi è impossibile cingere i fianchi di una ragazza con il mio braccio destro e serrare il suo sorriso nella mia mano sinistra, per poi tentare di studiare i due oggetti separatamente. Allo stesso modo, non ci è possibile separare la vita dalla materia vivente, allo scopo di studiare la sola materia vivente e le sue reazioni. Inevitabilmente, studiando la materia vivente e le sue reazioni, studiamo la vita stessa."

"[When I joined the Institute for Advanced Study in Princeton] I did this in the hope that by rubbing elbows with those great atomic physicists and mathematicians I would learn something about living matters. But as soon as I revealed that in any living system there are more than two electrons, the physicists would not speak to me. With all their computers they could not say what the third electron might do. The remarkable thing is that it knows exactly what to do. So that little electron knows something that all the wise men of Princeton don't, and this can only he something very simple."

"When I received the Nobel Prize, the only big lump sum of money I have ever seen, I had to do something with it. The easiest way to drop this hot potato was to invest it, to buy shares. I knew that World War II was coming and I was afraid that if I had shares which rise in case of war, I would wish for war. So I asked my agent to buy shares which go down in the event of war. This he did. I lost my money and saved my soul."

"If any student comes to me and says he wants to be useful to mankind and go into research to alleviate human suffering, I advise him to go into charity instead. Research wants real egotists who seek their own pleasure and satisfaction, but find it in solving the puzzles of nature."

"Research is to see what everybody has seen and think what nobody has thought."

"Discovery consists of looking at the same thing as everyone else and thinking something different."

"Life is water, dancing to the tune of macro molecules."

"I am not religious, but I am a pious man... A religious man has a definite religion. He says "God is there" or "God is there," "God is there." "Your god is not my god, and that's all." But the pious man, he just looks out with awe, and says, "where is God?" And "well, I don't understand it and I would like to know what this creation really means." That is a pious man, who is really touched by the greatness of nature and of the creation."

"It is probably this dual code of morals which underlies the break in... many leading politicians who begin their political efforts with the desire to improve the lot of their fellow men. Once they reach the top they tend to exchange their individual code of morals for the collective one... to serve abstract ideas, which have little to do with their people's well being, and they make war."

"Collective human suffering easily becomes an abstraction... being unable to multiply death or suffering by 100,000. This... is a number, an abstraction. One death is a tragedy. 100,000 deaths are statistics. So it must also seem to men in high offices."

"From on high a human life must look very small, a notion that moved Walt Whitman to sing about the arrogance and audacity of elected government officials. ...Unfortunately, this collective code of morals... [w]e all share... as soon as... we participate in government... when we go to the polls to elect hawks and vote the endless billions for war and... formidable machines for killing and destruction, and then go to church and ask for God's blessing."

"Between the two world wars, at the heydey of Colonialism, force reigned supreme. ...[I]t was natural for the weaker to lie down before the stronger. ...Gandhi, chasing out of his country... the greatest military power on earth... taught the world that there are higher things than force, higher even than life... [H]e proved that force had lost its suggestive power... information which did not reach the Pentagon or the government: we cannot win in win in Viet Nam because the people are willing to die faster than we can kill them."

"DNA... is the most wonderful thing in the world... Mankind went through epidemics, famine, and...trials, yet nature kept this... intact, because all life depends on it. ...[M]an has found a means to damage it. High energy radiation does so. ...There may ...be survivors after after an atomic war, but those... will be unable to produce a healthy progeny. Their progeny will be beset by abnormalities, monstrosities and diseases... and there will be no way back."

"The primary aim of science is to find... new truth. The search is the more successful the more it is directed towards... truth for its own sake, regardless of... possible use or application. ...If everything given to us by research were to be taken away, civilization would collapse and we would stand naked, searching for caves again."

"Even pure truth, which has no application... elevates life."

"Science is life-oriented. ...[A]rmies and armaments are death-oriented. Armies are instruments of organized manslaughter... All its tools are the tools of death... instruments of killing. ...[A] society dominated by the military is death-centered, as pointed out by in his famous Moratorium Speech."

"Out children came into this world with "clean and empty minds." What they learn... is markedly different from... children of the pre-War world. Today's adults look... through glasses of pre-War and pre-scientific values. They think... all the world needs a little bit of patching... The result... we get deeper... into trouble. The modern scientific revolution had made all human s age faster... as a consequence we have a hypocritical world... Our youth rejects this anachronism wholesale. ...They find everything a lie. The great political parties... out for profit and power, the military for domination, fattening itself with their young bodies... churches preaching love but raising no voice against the slaughter of undeveloped people... driving the world toward overpopulation... resisting family planning... always on the side of power. And they see while half of the children of the world go to sleep hungry... we spend hundreds of billions to raise our stack of nuclear bombs and missiles... They see... most political leaders... mindful only of... re-election... keeping power... with arguments which should be rejected by the simplest logic, refuting the great ideals on which our country was built."

"[T]here is only one medicine that will be effective against drug use: a livible, a restoration of faith in life—its dignity, value and longevity. Police raids and jail terms are not the answer."

"I am not dreaming of a Utopia, only of a world in which problems are not resolved by force but by intelligence, good will and equity; a world in which killing, no matter the reason, and the destruction of a fellow man's life or home, is a crime; a world in which our youth in which our youth will not have to spend their years studying organized manslaughter, in which neither force nor megatons nor poison gases will decide a nation's standing but the sum of its knowledge, its ethics, the gifts it makes to mankind, the happiness it gives to men, the measure in which it lifts human life."

"The battle... is for the minds of men; the outcome... does not depend on numbers of missiles, but on the question of which system can raise life higher, give more happiness... and raise the great undeveloped masses out of their misery. ...Now there are two parties: democracy and communism. Why not embark on a noble competition by showing which... can create a better, freer, happier life?"

"The great hope of mankind is still the United Nations."

"[B]rutalizing wars and military life... are capable of turning decent fellows into ers who can shoot women and children down in cold blood."

"Psalmus Humanus My Lord, Who are You? ... Are you the Universe itself? Or the Law which Ruled it? ... Are you the maker, or did I shape You, That I may share my loneliness and shun my responsibility? God! ...I am calling to You, for I am in trouble, Frightened of myself and my fellow men! ..."

"Szent-Györgyi's offbeat ideas came to Mr. Moss's attention in 1980 when he was promoting his book The Cancer Syndrome. "I was dubious about his work," Mr. Moss said. Then The Saturday Evening Post asked him to interview Szent-Györgyi and "I was just bowled over by him. Linus Pauling said he was the most charming man in science. He had this easy gift of winning people over.""

"It is difficult to get a hearing from busy men for even a great new truth."

"The brain is a mystery—it has been—and still will be. Not that we do not know many facts about it. The facts we know have indeed greatly multiplied in recent years, but they all fail to give us a key to the mystery of how it creates—if it does create—our thoughts and feelings; that is, said more concisely though less concretely, our mind."

"Natural science is a branch of knowledge by general consent not primarily based on the a priori. It […] observes and endeavours by observation to follow and trace the 'how' of what happens in Nature. It proceeds further to generalize about this 'how'. It tries to decipher something of it in the past and to forecast something of it in the future. Above all it expends its utmost pains on attempting to describe the 'how' fully and accurately by first-hand observation at this present."

"Today Nature looms larger than ever and includes more fully than ever ourselves. It is, if you will, a machine, but it is a partly mentalized machine, and in virtue of including ourselves it is a machine with human qualities of mind. It is a running stream of energy—mental and physical—and unlike man-made machines it is actuated by emotions, fears and hopes, dislikes and love. It bids fair to be master of this our planet—'it looks before and after'. To what or to whom does it owe this eminent and seemingly unique status? It answers unhesitatingly that it owes it to itself. But to the semi-divine assembly which looks on, that answer would be impertinent but for its saving ignorance. We may suppose that if they hear it the stars smile. Human thought is left wondering. What is it all for? Man is too small and too perishable to be the object of this whole. A counsel is 'let us endure and be quiet'—a counsel which is the easier to follow because it seems all that there is for us to do, at least at the present moment."

"The scientific journey has no end. It has only halting places—points at which the traveller can look round and survey."

"The 'motion' of an energy-system is its 'behaviour'. Various types of organization of system produce on that basis various types of behaviour. A grey rock, said Ruskin, is a good sitter. That is one type of behaviour. A darting dragon-fly is another type of behaviour. We call the one alive, the other not. But both are fundamentally balances of give and take of motion with their surround. To make 'life' a distinction between them is at root to treat them both artificially."

"The gap between 'the State' and 'a machine' is not so wide."

"The influence of mind on the doings of life makes mind an effective contribution to life. We can seize then how mind counts and has counted. That it has been evolved seems to assure us that it has counted. How it has counted would seem to be that the finite mind has influenced its individual's 'doing'. Lloyd Morgan, the biologist, urged that, 'the primary aim, object, and purpose of consciousness is control'. Dame Nature seems to have taken the like view."

"[M]an's life of all lives is the most completely and fully bound to earth because life's experience, wholly earthly, is in man's case the most complete and full. […] Man is the most, not the least, earthly of all creatures."

"In the great head-end which has been mostly darkness springs up myriads of twinkling stationary lights and myriads of trains of moving lights of many different directions. It is as though activity from one of those local places which continued restless in the darkened main-mass suddenly spread far and wide and invaded all. The great topmost sheet of the mass, that where hardly a light had twinkled or moved, becomes now a sparkling field of rhythmic flashing points with trains of traveling sparks hurrying hither and thither. The brain is waking and with it the mind is returning. It is as if the Milky Way entered upon some cosmic dance. Swiftly the head mass becomes an enchanted loom where millions of flashing shuttles weave a dissolving pattern, always a meaningful pattern though never an abiding one; a shifting harmony of subpatterns. Now as the waking body rouses, subpatterns of this great harmony of activity stretch down into the unlit tracks of the stalk-piece of the scheme. Strings of flashing and travelling sparks engage the lengths of it. This means that the body is up and rises to meet its waking day."

"In the training and in the exercise of medicine a remoteness abides between the field of neurology and that of mental health, psychiatry. It is sometimes blamed to prejudice on the part of the one side or the other. It is both more grave and less grave than that. It has a reasonable basis. It is rooted in the energy-mind problem. Physiology has not enough to offer about the brain in relation to the mind to lend the psychiatrist much help."

"A vast number, perhaps the numerical majority, of animal forms cannot be shown unequivocally to possess mind."

"[A]s followers of natural science we know nothing of any relation between thoughts and the brain, except as a gross correlation in time and space."

"Biology cannot go far in its subject before being met by mind."

"Science is the fruit of patient toil, sifting out facts and in search of more facts. It has no tilt against religion as such. It knows its own field to be vast, but also knows it limited."

"Mind, for anything perception can compass, goes therefore in our spatial world more ghostly than a ghost. Invisible, intangible, it is a thing not even of outline; it is not a 'thing'. It remains without sensual confirmation, and remains without it for ever. All that counts in life. Desire, zest, truth, love, knowledge, 'values', and, seeking metaphor to eke out expression, hell's depth and heaven's utmost height. Naked mind."

"And the pursuit whose quest is Nature's understanding, has this among its rewards, that as it progresses its truth is testable. Truth is a 'value'. The quest itself is therefore in a measure its own satisfaction. We receive the lesson that our advance to knowledge is of asymptotic type, even as continually approaching so continually without arrival. The satisfaction shall therefore be eternal."

"Natural knowledge has not forgone emotion. It has simply taken for itself new ground of emotion, under impulsion from and in sacrifice to that one of its 'values', Truth."

"For many years it was widely held that molecular biology was a completely useless subject, a 'fundamental' science of no interest to those working on practical matters"

"Current ideas of the uses of Model Organisms spring form the exemplars of the past and choosing the right organism for one's research is as important as finding the right problems to work on. In all my research these two problems have been closely intertwined."

"A lot of the things that have been accomplished in science have been accomplished on the basis of ignorance … in the sense that you import into the science people from outside. Because once you have an established science, it has got its high priests — the guys who know everything that will work or won't work. And they don't want to be bothered. So you have to have a challenge. And the great thing is that young people are ignorant, and we should catch them before they turn into the priesthood. So I think that science should have a much more daring approach."

"Even God wouldn’t get a grant today because somebody on the committee would say, oh those were very interesting experiments (creating the universe), but they’ve never been repeated. And then someone else would say, yes and he did it a long time ago, what’s he done recently? And a third would say, to top it all, he published it all in an un-refereed journal (The Bible)."

"Then we started clinical work ... and I just wasn't suited to that. I didn't like ... the whole structure of a teaching hospital. That is, I felt very much that treating patients as things is the wrong thing. And since I thought it was very hard to be a scientist and not do this, then I preferred not to do it at all. So, in fact, I think I am the only person who has ever passed medicine who had never seen a patient until his examination — because I never went. And, in fact, one of the great stories is that I failed my medicine because I was asked to smell this patient's breath and correctly diagnosed Macleans toothpaste where I should have diagnosed acetone."

"Well, I think my skills are in getting things started. ... In fact, that's what I enjoy most — it's the opening game. And I'm afraid that once it gets past that point I get rather bored with it and want to do other things. ... The other thing I'm good at is talking."

"I think for the first time we can attack the fundamental biology of man."

"Like Feynman, Brenner is witty and has won a Nobel Prize. But most important for a legend, Brenner, like Feynman, has this wonderful superiority complex, which results in irreverence, disdain for authority, and allergy to pomposity. This is what young starting scientists love."

"I am very conscious that there is no scientific explanation for the fact that we are conscious."

"I have lost a bit of my sight, much of my hearing. At conferences, I can't see the presentations and can't hear well. But I think more now than when I when I was twenty. The body can do whatever it likes. I am not the body: I am the mind."

"Man is ruined by servility, conformism, obsequiousness, rather than aggressiveness, which is much more common in the environment than within ourselves."

"In life one should never give in, surrender oneself to mediocrity, but rather move out of that grey area where everything is habit and passive resignation. One has to grow the courage to rebel."

"The women who changed the world never needed to show anything other than their own intelligence."

"I never had any hesitation or regrets in this sense. My life has been enriched by excellent human relations, work and interests. I have never felt lonely."

"Rare are those people who use the mind, few use the heart and really unique are those who use both."

"Everything came easy to me in life. I could always shake off difficulties, like water on a duck's wings."

"I'm an atheist: I don't know what it means to believe in God."

"Those who are lucky enough to have faith are granted with a great support in all stages of life. If instead of an anthropomorphous God, who rewards the good, one replaces the imperative chiselled in our genetic program that good deeds have a price in themselves, and that evil has its own punishment, both the non-believer and the believer will find the same answer."

"Better to add life to your days than days to your life."

"I consider imperfection a Darwinian spring of natural selection. For example, present day insects are identical to those of six million years ago: they were already perfect, and there was no reason for them to change. Man was instead imperfect, and this was the proxy for his own development and evolution."

"The young need to know how lucky they are to have been born in this splendid country, Italy."

"It is imperfection — not perfection — that is the end result of the program written into that formidably complex engine that is the human brain, and of the influences exerted upon us by the environment and whoever takes care of us during the long years of our physical, psychological and intellectual development."

"After centuries of dormancy, young women can now look toward a future moulded by their own hands."

"The allegations against Fidia cannot be true. The process for awarding Nobel prizes is so complex that it cannot be corrupted."

"She had this feeling for what was happening biologically. She was an intuitive observer, and she saw that something was making these nerve connections grow and was determined to find out what it was."

"She seemed able to face with equal equanimity the rigours of fascist cruelty and suppression that she was dealt as a Jew; the problems of practising underground medicine in wartime; the difficulties posed by prejudice and discrimination against women; and the near isolation and challenges of those working at the cutting edge of science."

"In the last few years there has been a harvest of books and lectures about the "Mysterious Universe." The inconceivable magnitudes with which astronomy deals produce a sense of awe which lends itself to a poetic and philosophical treatment. "When I consider thy heavens, the work of thy hands, the moon and the starts, whuch thou hast ordained: what is man that thou art mindful of him? The literary skill with which this branch of science has been exploited compels one's admiration, but also, a little, one's sense of the ridiculous. For other facts than those of astronomy, oother disciplines than of mathematics, can produce the same lively feelings of awe and reverence: the extraordinary finenness of their adjustments to the world outside: the amazing faculties of the human mind, of which we know neither whence it comes not whither it goes. In some fortunate people this reverence is produced by the natural bauty of a landscape, by the majesty of an ancient building, by the heroism of a rescue party, by poetry, or by music. God is doubtless a Mathematician, but he is also a Physiologist, an Engineer, a Mother, an Architect, a Coal Miner, a Poet, and a Gardener. Each of us views things in his own peculiar war, each clothes the Creator in a manner which fits into his own scheme. My God, for instance, among his other professions, is an Inventor: I picture him inventing water, carbon dioxide, and haemoglobin, crabs, frogs, and cuttle fish, whales and filterpassing organisms ( in the ratio of 100,000,000,000,000,000,000,000 to 1 in size), and rejoicing greatly over these weird and ingenious things, just as I rejoice greatly over some simple bit of apparatus. But I would nor urge that God is only an Inventor: for inventors are apt, as those who know them realize, to be very dull dogs. Indeed, I should be inclined rather to imagine God to be like a University, with all its teachers and professors together: not omittin the students, for he obviously possesses, judging from his inventions, that noblest human characteristic, a sense of humour."

"To suppose that chemistry and poetry are incompatible (as I am sure Prof Donnan would not do!), or that biology is inconsistent with a religious outlook on the world (I don not say with theology!) is to misunderstand entirely what the human mind, by contemplation and experiment, has achieved. By extreme specialization at intervals, by overloading the machine to its limit, discoveries and progress are made: but their bearing is best seen by letting the engine idle and giving oneself time to look around. The chemist and the poet are both right, the biologist and the saint: and each must pull up now and then to find whither he is going and to adjust his spectacles."

"All knowledge, not only that of the natural world, can be used for evil as well as good: and in all ages there continue to be people who think that its fruit should be forbidden. Does the future wlfare, therefore, of mankind depend of a refusal of science and a more intensive study of the Sermon on the Mount? There are others who hold the contray opinion, that more and more of science and its applications alone can bring prosperity and happiness to men. Both of these extremes views seem to me entirely wrong - though the second is the more perilous as more likely to be commonly accepted. The so-called conflict between science and religion is usually about words, too often the words of their unbalanced advocates: the reality lies somewhere in between. "Completeness and dignity", to use Tyndall's phrase, are brought to man by three main channels, first by the religiouos sentiment and its embodiment of ethical principles, secondly by the influence of what is beautiful in nature, human personality, or art, and thirdly, by the pursuit of scientific truth and its resolute use in improving human life. Some suppose that religion and beauty are incompatible: others, that the aesthetic has no relation to the scientific sense: both seem to me just as mistaken as those who hold that the scientific and the religious spirit are necessarily opposed. Co-operation is required, not conflict: for science can be used to express and apply the principles of ethics, and those principles themselves can guide the behaviour of scientific men: while the appreciation of what is good and beautiful can provide to both a vision of encouragement. Is there really then any special ethical dilemma which we scientific men, as distinct from other people, have to meet? I think not: unless it be to convince ourselves humbly that we are just like others in having moral issues to face. It is true that integrity of thought is the absolute condition of oour work, and that judgments of value must never be allowed to deflect our judgements of fact. But in this we are not unique. It is true that scientific research has opened up the possibility of unprecedented good, or unlimited harm, for manking: but the use is made of it depends in the end on the moral judgments of the whole community of men. It is totally impossible noew to reverse the process of discovery: it will certainly go on. To help to guide its use aright is not a scientific dilemma, but the honourable and compelling duty of a good citizen."

"As knowledge advances and scientific disciplines change, so do the disciplines impinging on them."

"In the period from 1920 to 1960, psychiatry derived its main intellectual impetus from psychoanalysis. During this phase, its most powerful antidisciplines were philosophy and the social sciences. Since 1960, psychiatry has begun (again) to derive its main intellectual challenge from biology, with the result that neurobiology has been thrust into the position of the new antidiscipline for psychiatry."

"In the near future, neurobiology will address a matter of more general and fundamental importance: the biology of human mental processes. ...Psychology and psychiatry can illuminate and define for biology the mental functions that need to be studied if we are to have a meaningful and sophisticated understanding of the biology of the human mind."

"The Age of Insight is a product of my... fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. ...I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna and document its three major phases."

"Five separate pulses of serotonin, designed to simulate five shocks to the tail, strengthened the synaptic connection for days and led to the growth of new synaptic connections... that did involve the synthesis of new protein."

"Jacques Monod... published a paper entitled "Genetic Regulatory Mechanisms in the Synthesis of Protein." Using bacteria as a model system, they made the remarkable discovery that genes can be regulated—that is, they can be switched on and off like a water faucet."

"What is learning but a set of sensory signals from the environment, with different forms of learning resulting from different types or patterns of sensory signals?"

"Jacob and Monod found that in bacteria, genes are switched on and off by other genes. This led them to distinguish between effector genes and regulatory genes. Effector genes encode effector proteins... which mediate specific cellular functions. Regulatory genes encode proteins called regulatory proteins, which switch the effector genes on or off."

"Jacob and Monod not only outlined a theory of gene regulation, they also discovered the first regulators of gene transcription. These regulators come in two forms—repressors, genes that encode the regulatory proteins that shut genes off, and as later work showed, activators, genes that encode the regulatory proteins that turn genes on."

"In the Jacob-Monod model, signals from a cell's environment activate regulatory proteins that switch on the genes encoding particular proteins. This led [Philip] Goelet and me to wonder whether the crucial step in switching on long-term memory in sensitization might involve similar signals and similar gene regulatory proteins."

"Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that, in the brain as in bacteria, genes are also servants of the environment. ...An environmental stimulus... activates modulatory interneurons that release serotonin. The serotonin acts on the sensory neuron to increase cyclic AMP and to cause protein kinase A and MAP kinase to move to the nucleus and activate CREB. The activation of CREB, in turn, leads to the expression of genes that changes the function and the structure of the cell."

"CREB's opposing regulatory actions provide a threshold for memory storage, presumably to ensure that only important, life-serving experiences are learned. Repeated shocks to the tail are a significant learning experience for an Aplysia, just as, say, practicing the piano or conjugating French verbs are to us: practice makes perfect, repetition is necessary for long-term memory. In principle, however, a highly emotional state... could bypass the normal restraints on long-term memory. In such a situation, enough MAP kinase molecules would be sent into the nucleus rapidly enough to inactivate all of the CREB-2 molecules, thereby making it easy for protein kinase A to activate CREB-1 and put the experience directly into long-term memory."

"Exceptionally good memory exhibited by some people may stem from genetic differences in CREB-2 that limit the activity of this repressor protein in relation to CREB-1."

"The same CREB switch is important for many forms of implicit memory in a variety of other species, from bees to mice to people."

"CPEB is the first self-propogating form of a prion known to serve a physiological function... perpetuation of synaptic facilitation and memory storage."

"The fact that a gene must be switched on to form a long-term memory shows clearly that genes are not simply determinants of behavior but are also responsive to environmental stimulation, such as learning."

"The growth and maintenance of new synaptic terminals makes memory persist. ...The ability to grow new synaptic connections as a result of experience appears to have been conserved throughout evolution. As an example... the cortical maps of the body surface are subject to constant modification in response to changing input from sensory pathways."

"Implicit memory is responsible not only for simple perceptual and motor skills but also, in principle, for the pirouettes of Margot Fonteyn, the trumpeting techniques of Wynton Marsalis, the accurate ground strokes of Andre Agassi, and the leg movements of an adolescent. Implicit memory guides us through well-established routines that are not consciously controlled."

"For all of us, explicit memory makes it possible to leap across space and time and conjure up events and emotional states that have vanished into the past yet somehow continue to live in our minds."

"Recall of memory is a creative process. What the brain stores is... only a core memory. Upon recall, this memory is then elaborated upon and reconstructed, with subtractions, additions, elaborations, and distortions."

"What biological processes enable me to review my own history with such emotional vividness?"

"Mountcastle discovered that tactile sensation is made up of several distinct modalities; for example, touch includes... hard pressure on the skin as well as a light brush... He found that each distinct submodality has its own private pathway within the brain and that this segregation is maintained at each relay..."

"Cajal revealed the precision of the interconnections between populations of individual nerve cells. Mountcastle, Hubel, and Wiesel revealed the functional significance of those patterns of interconnections. They showed that the connections filter and transform sensory information on the way to and within the cortex, and that the cortex is organized into functional compartments, or modules."

"Each sensory system first analyzes and deconstructs, then restructures the raw, incoming information to its own built-in connections and rules—shades of Immanuel Kant."

"Aspects of visual perception—motion, depth, form, and color—are segregated from one another and conveyed in separate pathways in the brain, where they are brought together and coordinated into a unified perception."

"Segregation occurs in the primary visual area of the cortex, which gives rise to two parallel pathways. ...the "what" pathway, carries information about the form of an object... the "where" pathway, carries information about the movement of the object in space: where the object is located."

"The idea that different aspects of visual perception might be handled in separate areas of the brain was predicted by Freud at the end of the nineteenth century. ...a cortical defect that affected [the] ability to combine aspects of vision into a meaningful pattern. ...defects, which Freud called agnosias (loss of knowledge)..."

"What strategy does the brain use to read itself out? That question, which is central to the unitary nature of conscious experience, remains one of the many unresolved mysteries of the new science of mind."

"The firing of individual nerve cells involved in perceptual and motor processing is modified by attention and decision making."

"Birds in which spatial memory is particularly important—those that store food at a large number of sites, for example—have larger hippocampuses than other birds. ...London taxi drivers have a larger hippocampus than others the same age. ...the size of their hippocampus continues to increase with time on the job."

"Long-term potentiation helps stabalize the internal representation of space, and... attention, a defining feature of explicit memory storage, modulates the representation of space."

"O'Keefe... argued that many forms of explicit memory (for example, memory for people and objects) use spatial coordinates... we typically remember people and events in a spatial context."

"Because we do not have a sensory organ dedicated to space, the representation of space is a quintessentially cognitive sensibility: it is the binding problem writ large."

"For some representations of space the brain typically uses egocentric coordinates (centered on the receiver)... For other behaviors... the brain uses allocentric coordinates (centered on the world)."

"We did not realize that the hippocampus is concerned with perception of the environment and therefore represents multisensory experience..."

"Unlike vision, touch, or smell, which are prewired and based on Kantian a priori knowledge, the spatial map presents us with a new type of representation, one based on a combination of a priori knowledge and learning. The general capability for forming spatial maps is built into the mind, but the particular map is not. Unlike neurons in a sensory system, place cells are not switched on by sensory stimulation. Their collective activity represents the location where the animal thinks it is."

"By merely observing the electrical activity in the brain, Libet could predict what a person would do before the person was actually aware of having decided to do it. This finding caused philosophers of mind to ask: If the choice is determined in the brain before we decide to act, where is free will? ...choice in action, as in perception, may reflect the importance of unconscious inference. Libet proposes that... just before the action is initiated, consciousness is recruited to approve or veto the action."

"Pernkopf was only one of many Austrians who were "rehabilitated" in the postwar period. Their rehabilitation underscores the tendency of Austria to forget, suppress, and deny the events of the Nazi period. ...Anton Pelinka ...has called this phenomenon the "great Austrian taboo." It is precisely this moral vacuum that induced Simon Wiesenthal to establish his documentation center for Nazi war crimes in Austria, not Germany."

"The history of Austrian culture and scholarship in the modern era largely paralleled the history of Austrian Jewry."

"The Viennese Kultusgemeinde... was going bankrupt... European governments typically compensate Jewish agencies... but the Austrian government's compensation was not adequate. ...I owe my existence in the United States to the generosity of the Viennese Kultusgemeinde."

"My hope is that the difference in the three generations' attitudes may signal a lessening of anti-Semitism in Austria."

"I continue to explore the science in which I work almost like a child, with naïve joy, curiosity, and amazement."

"I was astonished to discover that working in the laboratory—doing science in collaboration with interesting and creative people—is dramatically different from taking courses and reading about science."

"The life of a biological scientist in the United States is a life of discussion and debate—it is the Talmudic tradition writ large. ...The egalitarian structure of American science encourages this camaraderie. ...this would not—could not—have taken place in the Austria, the Germany, the France, or perhaps even the England of 1955."

"I have at times felt alone, uncertain, without a well-trodden path to follow. Every time I embarked on a new course, there were well-meaning people... who advised against it. I had to learn early on to be comfortable with insecurity and to trust my own judgement on key issues."

"We now understand that every mental state and every mental disorder is a disorder of brain function. Treatments work by altering the structure and function of the brain."

"...in various types of organisms, from snails to flies to mice to people. ...learning and memory, as well as synaptic and neuronal plasticity, represent a family of processes that share a common logic and some key components but vary in the details of their molecular mechanisms."

"I would like to develop a reductionist approach to the problem of attention by focusing on how place cells... create an enduring spatial map only when an organism is paying attention to its surroundings."

"The idea that we are unaware of much of out mental life, first developed by Hermann Helmholtz, is central to psychoanalysis. Freud has added the interesting idea that although we are not aware of most instances of mental processing, we can gain conscious access... by paying attention."

"Cori Bargmann... has studied two variants of C. elegans... The only difference between the two is one amino acid in an otherwise shared receptor protein. Transferring the receptor from a social worm to a solitary worm makes the solitary worm social."

"Giacomo Rizzolatti... calls these "mirror neurons" and suggests that they provide the first insight into imitation, identification, empathy, and possibly the ability to mime vocalization—the mental processes intrinsic to human interaction. Vilayanur Ramachandran has found evidence of comparable neurons in the premotor cortex of people. ...one can see a whole new area of biology opening up... that can give us a sense of what makes us social, communicating beings. An ambitious undertaking of this sort might... teach us something about the factors that give rise to tribalism, which is so often associated with fear, hatred, and intolerance of outsiders."

"The overarching ideas that have influenced my work and fueled my interest in conscious and unconscious memory derive from a perspective on mind that psychiatry and psychoanalysis opened up for me."

"It is much more meaningful and enjoyable to read the scientific literature about experiments you are involved in yourself than to read about science in the abstract."

"Once I have gotten into a problem, I find it extremely helpful to get a complete perspective, to learn what earlier scientists thought about it. I want to see not only what lines of thought proved to be productive, but also where and why certain other directions proved to be unproductive."

"I was very much influenced by the psychology of Freud and by early workers in the field of learning and memory—James, Thorndike, Pavlov, Skinner, and Ulric Neisser. Their thinking, and even their errors, provided a wonderfully rich cultural background for my later work."

"Nothing is more stimulating for self-education than working in a new area."

"Having been trained in history and the humanities, where one learns early on how depressing life can be, I am delighted to have ultimately switched to biology, where a delusional optimism still abounds."

"I entered Harvard to become a historian and left to become a psychoanalyst, only to abandon both... to follow my intuition that the road to a real understanding of mind must pass through the cellular pathways of the brain."

"The intellectual life of turn-of-the-century Vienna is in my blood: my heart beats in three-quarter time."

"The Age of Insight is a product of my subsequent fascination with the intellectual history of Vienna from 1890 to 1918, as well as my interest in Austrian modernist art, psychoanalysis, art history, and the brain science that is my life's work. In this book I examine the ongoing dialogue between art and science that had its origins in fin-de-siècle Vienna..."

"This dialogue between the ongoing research in brain science and art continue to this day. ...Such dialogues could help us explore the mechanisms in the brain that make perception and creativity possible, whether in art, the sciences, the humanities, or everyday life. In a larger sense, this dialogue could help make science part of our everyday experience."

"The portraits of the Viennese modernists, with their conscious and dramatic attempts to depict their subject's inner feelings, represent an ideal example of how psychological and biological insights can enrich our relationship with art."

"One of the characteristic features of Viennese life at this time was the continual, easy interaction of artists, writers, and thinkers with scientists."

"The function of the modern artist was not to convey beauty, but to convey new truths."

"The Vienna School of Art History, influenced in part by Sigmund Freud's psychological work, began to develop a science-based psychology of art that was initially focused on the beholder. Today, the new science of mind has... again focused on the beholder."

"I outline in simple terms... our current understanding of the cognitive psychological and neurobiological basis of perception, memory, emotion, empathy, and creativity. ...the principles of the viewer's response to art are applicable to all periods of painting."

"A brain scan may reveal the neural signs of depression, but a Beethoven symphony reveals what that depression feels like. Both perspectives are necessary if we are to fully grasp the nature of mind, yet they are rarely brought together."

"Much as Leonardo da Vinci and other Renaissance artists used the revelations of human anatomy to help them depict the body more accurately and compellingly, so, too, many contemporary artists may create new forms of representation in response to revelations about how the brain works."

"Reductionism can expand our vision and give us new insights into the nature and creation of art."

"Science may explain aspects of art but it will not replace the inspiration that art evokes..."

"Like other modern artists faced with the advent of the photography, Klimt sought newer truths that could not be captured by the camera. He... turned the artists view inward—away from the three-dimensional outside world and toward the multidimensional inner self and the unconscious mind."

"As the art historian Emily Braun has documented, Klimt read Darwin and became fascinated with the structure of the cell... Thus, the small iconographic images on Adelle's dress are not simply decorative... they are symbols of male and female cells: rectangular sperm and ovoid eggs. ...designed to match the sitter's seductive face and her full-blown reproductive capacities."

"The remarkable insight that characterized Klimt's later work was contemporaneous with Freud's psychological studies and presaged the inward turn that would pervade all fields of inquiry in Vienna in 1900. This period... was characterized by the attempt to make a sharp break with the past and to explore new forms of expression in art, architecture, psychology, literature, and music. It spawned an ongoing pursuit to link these disciplines."

"Viennese life at the turn of the century provided opportunities in salons and coffeehouses for scientists, writers, and artists to come together in an atmosphere that was at once inspiring, optimistic, and politically engaged. ...science was no longer the narrow and restrictive province of scientists but had become an integral part of Viennese culture. ...a paradigm for how an open dialogue can be achieved."

"Modernism began in the mid-nineteenth century as a response not only to the restrictions and hypocrisies of everyday life, but also as a reaction to the Enlightenment's emphasis on the rationality of human behavior. ...The founders of the Royal Society thought of God as a mathematician who had designed the universe according to logical and mathematical principles. The role of the scientist—the natural philosopher was to... decipher the codebook that God had used in creating the cosmos."

"The Modernist reaction to the Enlightenment came in the aftermath of the Industrial Revolution, whose brutalizing effects revealed that modern life had not become... mathematically perfect..."

"As astronomy and physics inspired the Enlightenment, so biology inspired Modernism. ...This new view led to a reexamination in art of the biological nature of human existence, as evident in Édouard Manet's Déjeuner sur l’Herbe... Manet's painting... reveals a theme... the complex relationship between the sexes and between fantasy and reality. ...also startlingly modern because of its style. Several decades before Cézanne began to collapse three dimension into two, Manet here had already flattened the viewer's sense of perspective..."

"In Vienna, Modernism had three main characteristics. The first was the new view of the human mind as being largely irrational by nature. ...they questioned what constitutes reality, what lies below the surface appearances of people, objects, and events. ...They discovered that ...people harbor not only unconscious erotic feelings, but also unconscious aggressive impulses that are directed against themselves as well as against others. Freud later called these dark impulses the death instinct."

"The Copernican revolution... revealed that the earth is not the center of the universe... The second, the Darwinian revolution... revealed that we are not created divinely or uniquely but instead evolved from simpler animals by a process of natural selection. The third great revolution, the Freudian revolution of Vienna 1900, revealed that we do not consciously control our own actions but are instead driven by unconscious motives. This... later led to the idea that human creativity... stems from conscious access to underlying, unconscious forces."

"The realization that our mental functioning is largely irrational was arrived at by several thinkers at the same time, including Friedrich Nietzsche... Freud, who was much influenced by both Darwin and Nietzsche... was its most profound and articulate exponent. ...Schnitzler, Klimt, Kokoschka, and Schiele also discovered and explored new aspects of our unconscious mental life. They understood women better than Freud... and they saw more clearly than Freud the importance of an infant's bonding to its mother. They even realized the significance of the aggressive instinct earlier than Freud did. ...Plato discussed unconscious knowledge ...pointing out that much of our knowledge is inherent in the psyche in latent form. ...Hermann von Helmholtz... advanced the idea that the unconscious plays a critical role in human visual perception."

"The fundamental mechanisms that Eric Kandel has revealed [in Aplysia] are also applicable to humans... Even if the road towards an understanding of complex memory functions still is long, the results... have provided a fundamental building stone. It is now possible to continue and, for instance, study how complex memory images are stored in the nervous system, and how it is possible to recreate the memory of earlier events..."

"In the early 1960s, Kandel made the bold decision to conduct research on an unlikely animal, the large sea snail Aplysia californica. Kandel found this invertebrate attractive for neuroscience research because it has fewer and larger neurons than more traditional laboratory animals. This simple neural system would subsequently serve as an invaluable model for understanding the cellular basis of learning."

"Throughout his career, Kandel has also been a student of the history of neuroscience. ...Kandel's fascination with the "giants" of neuroscience, as he calls them, became ironic when Kandel himself became a part of the history of neuroscience..."

"The duration of the life of men may be considerably increased. It would be true progress to go back to the simple dishes of our ancestors. … Progress would consist in simplifying many sides of the lives of civilised people."

"If chromosomes are broken by various means, the broken ends appear to be adhesive and tend to fuse with one another 2-by-2. This has been abundantly illustrated in the studies of chromosomal aberrations induced by X-ray treatment. It also occurs after mechanical rupture of ring-shaped chromosomes during somatic mitoses in maize and is assumed to occur during the normal process of crossing-over."

"When, through radiation or other causes, chromosomes are broken within a single nucleus, 2-by-2 fusions may occur between the broken ends. These fusions may lead to rearrangements of parts of the chromatin complement, giving rise to various chromosomal aberrations which are detected as reciprocal translocations, inversions, deficiencies, etc. Since, in the well-investigated cases, the breakages occurred within a single nucleus, the conditions that lead to fusions of broken ends could not easily be ascertained."

"An experiment conducted in the mid-nineteen forties prepared me to expect unusual responses of a genome to challenges for which the genome is unprepared to meet in an orderly, programmed manner. In most known instances of this kind, the types of response were not predictable in advance of initial observations of them. It was necessary to subject the genome repeatedly to the same challenge in order to observe and appreciate the nature of the changes it induces. Familiar examples of this are the production of mutation by X-rays and by some mutagenic agents. In contrast to such “shocks” for which the genome is unprepared, are those a genome must face repeatedly, and for which it is prepared to respond in a programmed manner. Examples are the “heat shock” responses in eukaryotic organisms, and the “SOS” responses in bacteria. Each of these initiates a highly programmed sequence of events within the cell that serves to cushion the effects of the shock. Some sensing mechanism must be present in these instances to alert the cell to imminent danger, and to set in motion the orderly sequence of events that will mitigate this danger. The responses of genomes to unanticipated challenges are not so precisely programmed. Nevertheless, these are sensed, and the genome responds in a descernible but initially unforeseen manner."

"In 1950, Barbara McClintock published a Classic PNAS article, “The origin and behavior of mutable loci in maize,” which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring."

"In the year of her election to the National Academy, she began the series of experiments that led her to transposition—work that many now see as the most important of her career. At the time, only she thought so. To most, her conclusions seemed too radical."

"When Barbara McClintock was awarded a Nobel Prize for her work on gene transposition in corn plants, the most striking thing about her was that she made her discoveries by listening to what the corn spoke to her, by respecting the life of the corn and "letting it McClintock says she learned "the stories" of the plants. She "heard them. She watched the daily green journeys of growth from carth toward sky and sun. She knew her plants in the way a healer or mystic would have known them, from the inside, the inner voices of corn and woman speaking to one another. As an Indian woman, I come from a long history of people who have listened to the language of this continent, people who have known that corn grows with the songs and prayers of the people, that it has a story to tell, that the world is alive...This intuitive and common language is what I seek for my writing, work in touch with the mystery and force of life, work that speaks a few of the many voices around us, and it is important to me that McClintock listened to the voices of corn. It is important to the continuance of life that she told the truth of her method and that it reminded us all of where our strength, our knowing, and our sustenance come from. It is also poetry, this science, and I note how often scientific theories lead to the world of poetry and vision, theories telling us how atoms that were stars have been transformed into our living, breathing bodies. And in these theories, or maybe they should be called stories, we begin to understand how we are each many people, including the stars we once were, and how we are in essence the earth and the universe, how what we do travels clear around the earth and returns. In a single moment of our living, there is our ancestral and personal history, our future, even our deaths planted in us and already growing toward their fulfillment. The corn plants are there, and like all the rest we are forever merging our borders with theirs in the world collective."

"We cannot expect in the immediate future that all women who seek it will achieve full equality of opportunity. But if women are to start moving towards that goal, we must believe in ourselves or no one else will believe in us; we must match our aspirations with the competence, courage and determination to succeed."

"Initially, new ideas are rejected. Later they become dogma, if you’re right. And if you’re really lucky you can publish your rejections as part of your Nobel presentation."

"We still live in a world in which a significant fraction of people, including women, believe that a woman belongs and want to belong exclusively in the home."

"We were witnessing the birth of a new era in endocrinology, one that started with Yalow."

"Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications not only for carcinogenesis by RNA viruses but also for the general understanding of genetic transcription: apparently the classical process of information transfer from DNA to RNA can be inverted."

"The world of animal viruses appears to offer an unfathomable diversity of specimens, but, as the molecular biology of the replication of many viruses has been studied, a pattern of behavior has emerged. The viruses can be divided into classes, each of which has its own method of transmitting its genetic information from one generation to the next and its own style of expressing its genetic information. Although in some cases the data are still fragmentary, it is possible to outline the behavior of these systems and to place them in a formal scheme."

"This milestone of biology's megaproject is the long-promised draft DNA sequence from the International Human Genome Sequencing Consortium (the public project). The sequence itself is available to all those connected to the Internet … In the paper in this issue, we are presented with a description of the strategy used to decipher the structures of the huge DNA molecules that constitute the genome, and with analyses of the content encoded in the genome. It is the achievement of a coordinated effort involving 20 laboratories and hundreds of people around the world. It reflects the scientific community at its best: working collaboratively, pooling its resources and skills, keeping its focus on the goal, and making its results available to all as they were acquired."

"As long as I have been in science, which is let's say 1960 to today, just about every five years there are major changes in technology that allow you to do things that you previously either said were just too hard or there was no way to do them — or which you hadn't imagined that you could ever do."

"The prominence of Watson and Crick and the Phage Group made Baltimore all the more desperate to do some real experimental biology. During the spring of his junior year, Baltimore became president of the Biology Club and enrolled in a microbiology seminar that discussed the advances of Luria, Delbrück, Lederberg, and others. But he was sick of just talking about biology. He had understood very quickly that designing and completing experiments were the accomplishments that make a biologist; gathering an encyclopedia knowledge of facts simply makes a good student."

"Viral genomes must make mRNA that can be read by host ribosomes ... David Baltimore (Nobel laureate) used this insight to describe a simple way to think about virus genomes ... The original Baltimore scheme missed one genome type: the gapped DNA of the Hepadnaviridae ..."

"Michail Fischberg was well aware of the value of genetics in developmental biology, and when I joined him, he had just started using Xenopus as a laboratory animal, on the grounds that it could be grown to sexual maturity within a year and that, as it is wholly aquatic, it is easy to keep in the laboratory. Xenopus can deliver eggs throughout the year, in contrast to the limited-season availability of eggs from Rana and European newts, the organisms of choice for European embryologists. The history of how a frog that naturally occurs only in Africa has come to be one of the half-dozen most used animals for research is bizarre (Gurdon & Hopwood 2000)."

"For these early results in Xenopus to be reproduced in mammals took nearly 40 years (Campbell et al. 1996; Wilmut et al. 1997) in sheep. A very important feature of these first successful mammalian nuclear transfer in sheep was the use of unfertilised eggs, as was actually used in amphibia. Earlier work with mice (McGrath and Solter 1984) used fertilised eggs. Although fertilised eggs can be used (Egli et al. 2007), synchronisation between nucleus and egg is harder to achieve than with the use of unfertilised eggs. A very elegant and important experiment that confirmed the general principle that cell differentiation proceeds with the retention of a complete set of genes was carried out using nuclei with a rearranged genome from mature mouse B or T donor cells (Hochedlinger and Jaenisch 2002). In the course of time, somatic cell nuclear transfer to eggs has been successful in the eggs of mice and other mammals (Wakayama et al. 1998). In each species there seem to be some technical requirements which have to be identified and overcome."

"Cells specialise in ways determined by the concentration of signal that they receive ... The best example of signaling between cells is by the signal molecule activin, discovered in embryos by Makoto Asashima and J. C. Smith."

"My own view of development is that one has to try to narrow things down to single entities, whether it's a cell or a nucleus or a molecule, and I'm often ridiculed because I always ask people what concentration their molecule is at, and they'll say that it doesn't matter. I'd say that concentration and time are the two critical things in development. You need to know the concentration, and you need to know how long it has to be there to make a difference – because for cells, a particular concentration of a molecule for a few seconds may not be the same as that concentration for 10 minutes. So I would take the view that what we really lack in developmental biology at the moment is any ability to determine the concentration of proteins, analogous to the measurement of nucleic acids using PCR."

"Gurdon's (1962) nuclear transplantation experiments showed that genes were neither lost nor permanently inactivated during development. Upon transfer of an intestinal cell nucleus into an enucleated egg, entire swimming tadpoles developed. However, the frequency of this event was low, unless nuclei were first injected into oocytes (DiBerardino et al., 1986), a step that might allow reprogramming by stripping the DNA of mitotically heritable regulatory influences. Thus, although these experiments provided strong evidence that differentiation was reversible, they did not determine whether genes were silenced by active or passive mechanisms in the course of development."

"The dream of every cell is to become two cells."

"Evolution is a tinkerer, not an engineer."

"Implicit in the devotion to purifying enzymes, is the faith of a dedicated biochemist of being able to reconstitute in a test tube anything a cell can do."

"These scientists, once young and eager, had become gnomes grappling hopelessly with problems far beyond their reach."

"This day relenting God Hath placed within my hand A wondrous thing; and God Be praised. At his command, Seeking His secret deeds With tears and toiling breath, I find thy cunning seeds, O million-murdering Death. I know this little thing A myriad men will save, O Death, where is thy sting? Thy victory, O Grave?"

"I believe the benefits of two civilizations – a European education followed by the freedom and opportunities of this country – have been essential to whatever contributions I have been able to make to science."

"The Genome Project has been a great adventure. It began as the dream of a few visionaries, was embraced by the entire scientific community, and achieved its goals with the cooperation of public and private institutions. This is the true story of a great scientific achievement in our time. The secret of its success includes many factors. The main one was the absolute dedication of many scientists, who believed they could achieve their goal despite the scarcity of technical means available. These means were quickly developed, such as new and fully automated technologies to determine the organisation of DNA, trace genes, read the messages they contain and their meanings. New approaches were used to determine gene activity, exploring the entire genome in a single step. The contribution of information technology has been extraordinary in this progress."

"My greatest contribution to biology was bringing Dulbecco."

"Every microbial species discovered is a new piece of the puzzle in understanding life's complexity"

"Microbes have been shaping the course of human history, from the development of agriculture to the prevention and treatment of diseases."

"The central dogma of molecular biology: DNA makes RNA makes protein."

"The evolution of life forms required billions of years for the first steps."

"The purpose of science is to develop a shared understanding of the natural world."

"Microbiology offers an understanding of the hidden world of microbes that is essential for understanding our own biology."

"Microbes don't just cause diseases, they also play critical roles in the health of our planet."

"Microbes are the unsung heroes of life on Earth."

"We must recognize the interconnectedness of all living things if we are to truly understand life."

"The biodiversity of microbes far exceeds that of all other organisms combined."

"Microbes have been shaping the course of evolution since the beginning of life."

"Microbes provide the foundation for all life on Earth."

"Through the study of microbes, we can unlock the secrets of life itself."

"The ability of microbes to adapt and evolve is unparalleled in the natural world."

"Microbes are the ultimate survivors, capable of thriving in some of the most extreme environments on Earth."

"Microbes hold the key to solving many of our pressing global challenges, from disease eradication to sustainable agriculture."

"The study of microbes is a never-ending journey of discovery."

"Microbiology is a field where curiosity meets application, paving the way for meaningful scientific advancements."

"By studying microbes, we can gain insights into our own biological processes and potentially unlock new therapeutic approaches."

"Microbial communities are like intricate ecosystems, with each member playing a unique role."

"Microbes are the true masters of adaptation, constantly evolving to overcome challenges."

"From the most remote landscapes to the depths of the ocean, microbes are everywhere."

"From the tiniest single-celled organisms to complex microbial communities, microbes hold immense scientific value and hold the secrets to the origins of life."