Malaria

"Bringing to his work the utmost vitality of a strong race and the highest aspirations for economic property, albeit attained through a Homeric struggle, man in the Amazon (...) will quite soon regret his own daring, upon the destruction of all his accumulated energies. Entire waves of people from Ceará, valiant people who exemplify our national resistance and tenacity, are decimated by malaria in a short space of time! Those who do not perish, those whose uncertain fate was less brutal, these return, bearing the remains of their sickness in the form of permanent organic lesions."

"Malaria is a focal disease whose distribution is influenced by literally dozens of factors related both to human, mosquito, and parasite populations and to the environment."

"I have failed in finding parasites in mosquitoes fed on malaria patients, but perhaps I am not using the proper kind of mosquito."

"This day relenting God Hath placed within my hand A wondrous thing; and God Be praised. At His command, Seeking His secret deeds With tears and toiling breath, I find thy cunning seeds, O million-murdering Death. I know this little thing A myriad men will save. O Death, where is thy sting? Thy victory, O Grave? [Poem he wrote following the discovery that the malaria parasite was carried by the amopheline mosquito]"

"I can think of a few microorganisms, possibly the tubercle bacillus, the syphilis spirochete, the malarial parasite, and a few others, that have a selective advantage in their ability to infect human beings, but there is nothing to be gained, in an evolutionary sense, by the capacity to cause illness or death. Pathogenicity may be something of a disadvantage for most microbes."

"We are issuing this joint statement to highlight the important role that physicians, pharmacists and health systems play in being just stewards of health care resources during times of emergency and national disaster. We are aware that some physicians and others are prophylactically prescribing medications currently identified as potential treatments for COVID-19 (e.g., or hydroxychloroquine, ) for themselves, their families, or their colleagues; and that some pharmacies and hospitals have been purchasing excessive amounts of these medications in anticipation of potentially using them for COVID-19 prevention and treatment. We strongly oppose these actions. At the same time, we caution hospitals, health systems, and individual practitioners that no medication has been FDA-approved for use in COVID-19 patients, and there is no incontrovertible evidence to support of medications for COVID-19. Stockpiling these medications—or depleting supplies with excessive, anticipatory orders—can have grave consequences for patients with conditions such as or if the drugs are not available in the community. The health care community must collectively balance the needs of patients taking medications on a regular basis for an existing condition with new prescriptions that may be needed for patients diagnosed with COVID-19. Being just stewards of limited resources is essential."

"We are further concerned by the confusion that may result from various state government agencies and boards issuing emergency rules limiting or restricting access to chloroquine, hydroxychloroquine or other emerging therapies or requiring new procedures for physicians and other healthcare professionals and patients. If these bodies promulgate new rules, we urge that they emphasize professional responsibility and leave room for professional judgment. We further urge that patients already on these medications should not be impacted by new laws, rules or other guidance. In a time of national pandemic, now is not the time for states to issue conflicting guidance, however well-intentioned, that could lead to unintended consequences. We applaud the ongoing efforts to conduct clinical trials and generate evidence related to these and other medications during a time of pandemic. We are also encouraged that some pharmaceutical manufacturers are increasing production of high-demand medications as well as supplying them for use in clinical trials."

"Hydroxychloroquine has been studied as a possible antiviral therapy for many decades. Despite showing evidence of activity against several viruses in the laboratory, it never showed success in randomized clinical trials."

"President Trump doubled down Sunday on his push for the use of an anti-malarial drug against the coronavirus, issuing that goes well beyond scant evidence of the drug's effectiveness as well as the advice of doctors and experts. Mr. Trump's recommendation of hydroxychloroquine, for the second day in a row at a White House briefing, was a striking example of his brazen willingness to distort and outright defy expert opinion and when it does not suit his agenda."

"Standing alongside two top public health officials who have declined to endorse his call for widely administering the drug, Mr. Trump suggested that he was speaking on gut instinct and acknowledged that he had no expertise on the subject. Saying that the drug is "being tested now," Mr. Trump said that "there are some very strong, powerful signs" of its potential, although health experts say that the data is extremely limited and that more study of the drug's effectiveness against the coronavirus is needed. [...] Mr. Trump, who once predicted that the virus might "miraculously" disappear by April because of warm weather, and who has rejected on issues like climate change, was undaunted by skeptical questioning. "What do you have to lose?" Mr. Trump asked, for the second day in a row, saying that terminally ill patients should be willing to try any treatment that has shown some promise."

"Even as Mr. Trump has promoted the drug, which is also often prescribed for patients with lupus, it has created rifts within his own coronavirus task force. And while many hospitals have chosen to use hydroxychloroquine in a desperate attempt to treat dying patients who have few other options, others have noted that it carries serious risks. In particular, the drug can cause a that can lead to ."

"Hydroxychloroquine has not been proved to work against Covid-19 in any significant clinical trials. A small trial by Chinese researchers made public last week found that it helped speed the recovery in moderately ill patients, but the study was not peer-reviewed and had significant limitations. Earlier reports from France and China have drawn criticism because they did not include control groups to compare treated patients with untreated ones, and researchers have called the reports anecdotal. Without controls, they said, it is impossible to determine whether the drugs worked. But Mr. Trump on Sunday dismissed the notion that doctors should wait for further study."

"There are side effects to hydroxychloroquine. It causes psychiatric symptoms, cardiac problems and a host of other bad side effects. [...] There may be a role for it for some people, but to tell Americans 'you don't have anything to lose,' that's not true. People certainly have something to lose by taking it indiscriminately."

"Now we're working with the states in almost all instances, but we have a great system. And the other thing that we bought a tremendous amount of is the hydroxy chloroquine]]. Hydroxy chloroquine, which I think is, you know, it's a great malaria drug. It's worked unbelievably. It's a powerful drug on malaria and there are signs that it works on this, some very strong signs and in the meantime it's been around a long time. It also works very powerfully on lupus, so there are some very strong powerful signs and we'll have to see because again, it's tested."

"Now this is a new thing that just happened to as the invisible enemy we call it. And if you can, if you have a no signs of heart problems, the , which will kill certain things that you don't want living within your body. It's a powerful drug. If you don't have a problem, a heart problem, we would say, let your doctor think about it, but as a combination, I think they're going to be, I think there's two things that should be looked at very strongly. Now, we have purchased and we have stockpiled 29 million pills of the hydroxy chloroquine, 29 million. A lot of drug stores have them by prescription and also, and they're not expensive. Also, we're sending them to various labs. Our military, we're sending them to the hospitals, we're sending them all over. I just think it's something, you know the expression, I've used it for certain reasons."

"What do you have to lose? What do you have to lose? And a lot of people are saying that when … and are taking it, if you're a doctor, a nurse, a first responder, a medical person going into hospitals, they say taking it before the fact is good, but what do you have to lose? They say, take it, I'm not looking at it one way or the other, but we want to get out of this. If it does work, it would be a shame if we didn't do it early. But we have some very good signs. So that's hydroxy chloroquine and as azithromycin, and again, you have to go through your medical people get the approval. But I've seen things that I sort of like, so what do I know? I'm not a doctor, I'm not a doctor, but I have common sense."

"The FDA feels good about it. They've, as you know, they've approved it. They gave it a rapid approved approval. And the reason because it's been out there for a long time and they know the side effects and they also know the potential. So based on that, we have sent it throughout the country. We have it stockpiled about 29 million doses, 29 million doses. We have a lot of it. We hope it works. Driven by the goal of the brightest minds in science. We have the brightest minds in science, but we were driven by the goal of getting rid of this plague, getting rid of this scourge, getting rid of this virus. These brilliant minds are working on the most effective antiviral therapies and vaccines. We are working very, very hard. I have met many of the doctors that are doing it. These are doctors that are working so hard on vanquishing the virus."

"I want them to try it. It may work, and it may not work. But if it doesn't work, it's nothing lost by doing it. Nothing. Because we know long-term what I want. I want to save lives, and I don't want it to be in a lab for the next year-and-a-half as people are dying all over the place. In France, they had a very good test. They're continuing. But we don't have time to go and say, gee, let's take a couple of years and test it out, and let's go and test with the test tubes and the laboratories. We don't have time. I'd love to do that, but we have people dying today. As we speak, there are people dying. If it works, that'd be great. If it doesn't work, we know for many years malaria, it's incredible what it's done for malaria. It's incredible what it's done for lupus, but it doesn't kill people."

"Speaker to Anthony Fauci: And would you also weigh in on this issue of hydroxychloroquine? What do you think about this and what is the medical evidence?"

"Fauci suppressed off-label use of hydroxychloroquine by encouraging discussions of it to be pulled from social media, by sabotaging its clinical trials by testing doses six times the recommended levels (p. 26), and by pulling sixty-three million doses of the medicine off the market, safely away from covid sufferers they could have helped (p. 28). Fauci also provided cover for those who threatened doctors and pharmacists with loss of licenses and jobs for prescribing and dispensing hydroxychloroquine for covid (pp. 31–32). The story of ivermectin is similar."