Sankie Mthembi-Mahanyele (née Mthembi; born 23 March 1951), formerly known as Sankie Mthembi-Nkondo or Sankie Nkondo, is a South African politician, diplomat, and former anti-apartheid activist. She was the Minister of Housing from 1995 to 2003 and served as Deputy Secretary-General of the African National Congress (ANC) from 2002 to 2007.